https://uvadoc.uva.es/handle/10324/1210 Dpto. Biología Celular, Histología y Farmacología - Capítulos de monografías 2026-04-13T15:31:05Z https://uvadoc.uva.es/handle/10324/82049 Nuestros alumnos son nativos digitales y las metodologías tradicionales ya no tienen en ellos el mismo impacto que tenían hace unos años. Por esta razón, las nuevas metodologías docentes están cobrando gran interés, destacando entre ellas la gamificación. Entre las diferentes actividades de gamificación destaca el desarrollo y realización de escape rooms (ERs, salas de escape) virtuales. Este trabajo muestra el resultado de la implantación, durante dos cursos académicos consecutivos, de ERs virtuales como herramienta de aprendizaje en la asignatura Histología Médica del Grado en Biomedicina y Terapias Avanzadas, con el objetivo principal de afianzar los conocimientos impartidos. La asignatura se divide en diferentes bloques temáticos y las ERs se basaron en los que presentan mayor dificultad de comprensión para nuestro alumnado. Del análisis de los resultados podemos concluir que la implantación de esta nueva metodología permite afianzar conocimientos teóricos y prácticos de la asignatura de una forma amena y motivadora y que su realización, de forma presencial, hace que nuestros alumnos integren los conocimientos impartidos de una manera continuada a lo largo del cuatrimestre, favoreciendo, por lo tanto, el proceso de aprendizaje y la superación de la asignatura de una manera más satisfactoria. 2025-01-01T00:00:00Z https://uvadoc.uva.es/handle/10324/71683 Mesenchymal tissues can provide a source of stem cells (MSCs) that are readily available, non-immunogenic, and have tremendous regenerative and anti-inflammatory properties. For these reasons, MSCs have emerged as very attractive candidates for cell-based therapies in numerous and diverse clinical applications including the treatment of ocular surface diseases such as limbal stem cell deficiency, dry eye disease, or even as a potential therapy to improve corneal allograft survival. Although some of the current preclinical evidence has already been successfully translated into clinical applications, work must continue to overcome all of the scientific and technical challenges that remain unsolved. This book chapter summarizes the main preclinical and clinical evidence that strongly supports MSC-based therapies as safe and effective treatments for the regeneration of the ocular surface. 2023-01-01T00:00:00Z https://uvadoc.uva.es/handle/10324/71681 Cultured limbal epithelial stem cell transplantation is a clinical procedure used to regenerate the corneal epithelium in patients with limbal stem cell deficiency. The protocols used to expand limbal epithelial cells in vitro need to be optimized, since the scarcity of human ocular tissue donors is limiting the potential use of this procedure. Here, we describe a method to consecutively expand a single human limbal explant. With this method it is possible to obtain up to three limbal epithelial primary cultures from the same explant, thus increasing the efficiency of the in vitro cell culture. 2020-01-01T00:00:00Z https://uvadoc.uva.es/handle/10324/60179 In December 2019, Wuhan City in China officially declared the presence of an unknown virus (now called SARS-Cov-2) that soon gained pandemic status. The SARS-Cov-2 or COVID-19 pandemic quickly led to the closure of Universities and colleges following the advice of public Health officials to maintain social distancing (Murphy, 2020). Consequently, educational institutions quickly adopted e-learning under the distance education mode (Morgan, 2020). At University of Valladolid (Spain), two of the degrees with the highest number of new students are the Bachelor’s Degree (BD) in Medicine and the BD in Nursing, which also have subjects with a very important practical part. Two of these subjects are Medical Biology and Biology, in the first year of both degrees. The use of the optical microscope is essential to carry out the practical work in these subjects during which students not only manipulate and observe materials using the microscope, but also engage intellectually, using and applying theoretical concepts. 2023-01-01T00:00:00Z