Show simple item record

dc.contributor.authorKumar, Lalit
dc.contributor.authorPivniouk, Vadim
dc.contributor.authorFuente García, Miguel Ángel de la 
dc.contributor.authorLaouini, Dhafer
dc.contributor.authorGeha, Raif S.
dc.date.accessioned2015-04-08T12:30:39Z
dc.date.available2015-04-08T12:30:39Z
dc.date.issued2002
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 2002, vol. 99, n. 2. p. 884-889es
dc.identifier.issn1091-6490es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/10153
dc.descriptionProducción Científicaes
dc.description.abstractThe adapter SLP-76 is essential for thymocyte development. SLP-76−/− mice were reconstituted with SLP-76 deletion mutant transgenes to examine the role of SLP-76 domains in T cell development and function. The N-terminal domain deletion mutant completely failed to restore thymocyte development. Mice reconstituted with Gads-binding site and SH2 domain deletion mutants had decreased thymic cellularity, impaired transition from double to single positive thymocytes, and decreased numbers of mature T cells in the spleen. Calcium mobilization and extracellular signal-regulated protein kinase activation were decreased in the Gads-binding site mutant but almost normal in the SH2 domain mutant. T cells from both mutants failed to proliferate following T cell antigen receptor ligation. Nevertheless, both mutants mounted partial cutaneous hypersensitivity responses and normal T cell dependent IgG1 antibody responses. These results indicate differential roles for SLP-76 domains in T cell development, proliferation and effector functions.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectBiología moleculares
dc.titleDifferential role of SLP-76 domains in T cell development and functiones
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1073 pnas.022619199es
dc.relation.publisherversionhttps://www.pnas.org/content/99/2/884
dc.identifier.publicationfirstpage884es
dc.identifier.publicationissue2es
dc.identifier.publicationlastpage889es
dc.identifier.publicationtitlePNASes
dc.identifier.publicationvolume99es
dc.peerreviewedSIes
dc.rightsAttribution-NonCommercial-NoDerivatives 3.0 International


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record