dc.contributor.author | Kumar, Lalit | |
dc.contributor.author | Pivniouk, Vadim | |
dc.contributor.author | Fuente García, Miguel Ángel de la | |
dc.contributor.author | Laouini, Dhafer | |
dc.contributor.author | Geha, Raif S. | |
dc.date.accessioned | 2015-04-08T12:30:39Z | |
dc.date.available | 2015-04-08T12:30:39Z | |
dc.date.issued | 2002 | |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, 2002, vol. 99, n. 2. p. 884-889 | es |
dc.identifier.issn | 1091-6490 | es |
dc.identifier.uri | http://uvadoc.uva.es/handle/10324/10153 | |
dc.description | Producción Científica | es |
dc.description.abstract | The adapter SLP-76 is essential for thymocyte development. SLP-76−/− mice were reconstituted with SLP-76 deletion mutant transgenes to examine the role of SLP-76 domains in T cell development and function. The N-terminal domain deletion mutant completely failed to restore thymocyte development. Mice reconstituted with Gads-binding site and SH2 domain deletion mutants had decreased thymic cellularity, impaired transition from double to single positive thymocytes, and decreased numbers of mature T cells in the spleen. Calcium mobilization and extracellular signal-regulated protein kinase activation were decreased in the Gads-binding site mutant but almost normal in the SH2 domain mutant. T cells from both mutants failed to proliferate following T cell antigen receptor ligation. Nevertheless, both mutants mounted partial cutaneous hypersensitivity responses and normal T cell dependent IgG1 antibody responses. These results indicate differential roles for SLP-76 domains in T cell development, proliferation and effector functions. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/ | |
dc.subject | Biología molecular | es |
dc.title | Differential role of SLP-76 domains in T cell development and function | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1073 pnas.022619199 | es |
dc.relation.publisherversion | https://www.pnas.org/content/99/2/884 | |
dc.identifier.publicationfirstpage | 884 | es |
dc.identifier.publicationissue | 2 | es |
dc.identifier.publicationlastpage | 889 | es |
dc.identifier.publicationtitle | PNAS | es |
dc.identifier.publicationvolume | 99 | es |
dc.peerreviewed | SI | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 3.0 International |
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