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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/13823

    Título
    Early natural killer cell counts in blood predict mortality in severe sepsis
    Autor
    Andaluz Ojeda, DavidAutoridad UVA
    Iglesias, Verónica
    Bobillo, Felipe
    Almansa Mora, RaquelAutoridad UVA
    Rico, Lucía
    Gandía Martínez, Francisco
    Loma, Ana María
    Nieto, Concepción
    Diego, Rosa
    Ramos, Epifanio
    Nocito Colón, Mercedes
    Resino, Salvador
    Eiros Bouza, José MaríaAutoridad UVA Orcid
    Tamayo Gómez, EduardoAutoridad UVA
    Ortiz de Lejarazu Leonardo, RaúlAutoridad UVA
    Bermejo Martín, Jesús FranciscoAutoridad UVA Orcid
    Año del Documento
    2011
    Editorial
    BioMed Central
    Descripción
    Producción Científica
    Documento Fuente
    Critical Care, 2011, 15(5):R243
    Zusammenfassung
    In an attempt to evaluate the quantitative changes in the status of immunocompetence in severe sepsis over time and its potential influence on clinical outcome, we monitored the evolution of immunoglobulins (Igs) (IgG, IgA and IgM), complement factors (C3 and C4) and lymphocyte subsets (CD4+ T cells, CD8+ T cells, B cells (CD19+) and natural killer (NK) cells (CD3-CD16+CD56+)) in the blood of 50 patients with severe sepsis or septic shock at day 1, day 3 and day 10 following admission to the ICU. Twenty-one patients died, ten of whom died within the 72 hours following admission to the ICU. The most frequent cause of death (n = 12) was multiorgan dysfunction syndrome. At day 1, survivors showed significantly higher levels of IgG and C4 than those who ultimately died. On the contrary, NK cell levels were significantly higher in the patients who died. Survivors exhibited a progressive increase from day 1 to day 10 on most of the immunological parameters evaluated (IgG, IgA, IgM, C3, CD4+, CD8+ T cells and NK cells). Multivariate Cox regression analysis, including age, sex, APACHE II score, severe sepsis or septic shock status and each one of the immunological parameters showed that NK cell counts at day 1 were independently associated with increased risk of death at 28 days (hazard ratio = 3.34, 95% CI = 1.29 to 8.64; P = 0.013). Analysis of survival curves provided evidence that levels of NK cells at day 1 (> 83 cells/mm3) were associated with early mortality. Our results demonstrate the prognostic role of NK cells in severe sepsis and provide evidence for a direct association of early counts of these cells in blood with mortality.
    Materias (normalizadas)
    Septicemia - Mortalidad
    ISSN
    1364-8535
    Revisión por pares
    SI
    DOI
    10.1186/cc10501
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/13823
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP03 - Artículos de revista [102]
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    Nombre:
    PD-241.pdf
    Tamaño:
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    Descripción:
    PD-241
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