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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/13852

    Título
    Antiretroviral recommendations may influence the rate of transmission of drug-resistant HIV type 1
    Autor
    Mendoza, Carmen de
    Rodríguez, Carmen
    Eiros Bouza, José MaríaAutoridad UVA Orcid
    Colomina, Javier
    Alcacer García, Federico
    Leiva, Pilar
    Torre Cisneros, Julián
    Aguero, Jesús
    Pedreira, José
    Viciana Ramos, María Isabel
    Corral, Angélica
    Romero, Jorge del
    Ortiz de Lejarazu Leonardo, RaúlAutoridad UVA
    Soriano, Vincent
    Año del Documento
    2005
    Editorial
    Oxford University Press
    Descripción
    Producción Científica
    Documento Fuente
    Clinical Infectious Diseases, 2005, vol. 41 ( 2 ), 227-232
    Abstract
    Human immunodeficiency virus (HIV) treatment guidelines have evolved, shifting from more-aggressive to more-conservative approaches. The potential impact of these shifts on the transmission of drug-resistant virus is unknown. Drug-resistance genotypes were examined in all consecutive patients with recent HIV type 1 (HIV-1) seroconversion (hereafter, "HIV-1 seroconverters") seen at 10 Spanish hospitals since 1997. During the same period, the proportion of patients with chronic HIV-1 infection having undetectable viremia was examined, to estimate the extent and effectiveness of antiretroviral therapy. A total of 141 recent HIV-1 seroconverters were identified, 67.4% of whom were men who have sex with men. The rate of primary drug-resistance mutations, by year of infection, was 33.3% for 1997, 29.4% for 1998, 20% for 1999, 14.3% for 2000, 3.4% for 2001, 15.4% for 2002, and 10.9% for 2003. On the other hand, the proportion of 8388 persons with chronic HIV-1 carriage who had an undetectable virus load was 33.4% for 1997, 34.6% for 1998, 39.7% for 1999, 47.5% for 2000, 52.9% for 2001, 39.7% for 2002, and 58.1% for 2003. A significant inverse correlation between transmission of drug-resistant HIV-1 and undetectable virus load was found (r=-0.955, by Spearman's test; P=.001). The lowest rate of transmission of drug-resistant HIV-1 was seen in 2001, when relatively "aggressive" treatment guidelines were used. Transmission of drug-resistant HIV-1 increased in 2002, in parallel with a reduction in the number of patients with chronic HIV-1 carriage and undetectable virus load, reflecting the popularity of drug holidays or treatment interruptions. The rate of drug resistance in recent HIV-1 seroconverters inversely correlates with the proportion of chronically HIV-1-infected individuals who have undetectable virus loads in the same region, which indirectly reflects antiretroviral treatment rules at any given time.
    Materias (normalizadas)
    SIDA (Enfermedad) - Tratamiento
    ISSN
    1058-4838
    Revisión por pares
    SI
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/13852
    Derechos
    openAccess
    Collections
    • DEP03 - Artículos de revista [32]
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