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dc.contributor.authorTamayo Gómez, Eduardo 
dc.contributor.authorÁlvarez González, Francisco Javier 
dc.contributor.authorAlonso, Oscar
dc.contributor.authorCastrodeza Sanz, José Javier 
dc.contributor.authorBustamante, Rosa
dc.contributor.authorGómez Herreras, José Ignacio 
dc.contributor.authorFlórez, Santiago
dc.contributor.authorRodríguez, Roberto
dc.date.accessioned2016-01-27T12:31:53Z
dc.date.available2016-01-27T12:31:53Z
dc.date.issued2008
dc.identifier.citationActa Anaesthesiologica Scandinavica,2008; 52(9): 1204–1212es
dc.identifier.issn0001-5172es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/15623
dc.descriptionProducción Científicaes
dc.description.abstractBackground: Systemic inflammatory response frequently occurs after coronary artery bypass surgery and is strongly correlated with the risk of postoperative morbidity and mortality. This study tests the hypothesis that the priming of the extracorporeal circuit with colloid solutions results in less inflammation in patients undergoing cardiac surgery than priming with crystalloid solutions. Methods: A prospective, randomized studywas designed. Forty-four patients undergoing elective coronary artery bypass grafting were randomly allocated to one of two groups: 22 patients primed with Ringer’s lactate (RL) solution and 22 patients primed with gelatin-containing solution during the surgery. Plasma levels of interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-a, C-reactive protein (CRP) and, complement 4 were measured during the surgical intervention and over the following 48 postoperative hours. Cytokine levels were measured by enzyme-linked assays from plasma samples obtained at specific time points pre- and post-operatively. Results: In both groups the serum levels of the pro-inflammatory cytokines (IL-6, IL-8, TNF-a), CRP, complement 4, and leukocytes increased significantly over the baseline, although no significant differences were observed between the two groups. The operation time, blood loss, need for inotropic support, extubation time, and length of intensive care unit stay did not differ significantly between the two groups. Conclusion: Priming with gelatin vs. RL produces no significant differences in the inflammatory response in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherWileyes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCardiovascular, Aparato - Cirugíaes
dc.titleThe inflammatory response to colloids and crystalloids used for pump priming during cardiopulmonary bypasses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1111/j.1399-6576.2008.01758.xes
dc.identifier.publicationfirstpage1204es
dc.identifier.publicationissue9es
dc.identifier.publicationlastpage1212es
dc.identifier.publicationtitleActa Anaesthesiologica Scandinavicaes
dc.identifier.publicationvolume52es
dc.peerreviewedSIes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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