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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/21683

    Título
    Positive airway pressure and electrical stimulation methods for obstructive sleep apnea treatment: a patent review (2005-2014)
    Autor
    Álvarez González, DanielAutoridad UVA Orcid
    Gutierrez Tobal, Gonzalo CésarAutoridad UVA Orcid
    Campo Matias, Félix delAutoridad UVA Orcid
    Hornero Sánchez, RobertoAutoridad UVA Orcid
    Año del Documento
    2015
    Editorial
    Taylor & Francis
    Descripción
    Producción Científica
    Documento Fuente
    Expert Opinion on Therapeutic Patents, 2015, vol. 25:9,p. 971-989
    Resumo
    Introduction. Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a major health problem with significant negative effects on the health and quality of life. Continuous positive airway pressure (CPAP) is currently the primary treatment option and it is considered the most effective therapy for OSAHS. Nevertheless, comfort issues due to improper fit to patient’s changing needs and breathing gas leakage limit the patient’s adherence to treatment. Areas covered. The present patent review describes recent innovations in the treatment of OSAHS related to optimization of the positive pressure delivered to the patient, methods and systems for continuous self-adjusting pressure during inspiration and expiration phases, and techniques for electrical stimulation of nerves and muscles responsible for the airway patency. Expert opinion. In the last years, CPAP-related inventions have mainly focused on obtaining an optimal self-adjusting pressure according to patient’s needs. Despite intensive research carried out, treatment compliance is still a major issue. Hypoglossal electrical nerve stimulation could be an effective secondary treatment option when CPAP primary therapy fails. Several patents have been granted focused on selective stimulation techniques and parameter optimization of the stimulating pulse waveform. Nevertheless, there remain important issues to address, like effectiveness and adverse events due to improper stimulation.
    Materias (normalizadas)
    Airflow limitation
    ISSN
    1354-3776
    Revisión por pares
    SI
    DOI
    10.1517/13543776.2015.1054094
    Patrocinador
    Ministerio de Economía y Competitividad (TEC2011-22987)
    Junta de Castilla y León (VA059U13)
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/21683
    Derechos
    openAccess
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    Alvarez_etal_2015_ExpertOpiniononTherapeuticPatents_post-review.pdf
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    Universidad de Valladolid

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