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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/21766

    Título
    Mineralization and bone regeneration using a bioactive elastin-like recombinamer membrane
    Autor
    Klymov, Alexey
    Reza Nejadnik, M.
    Alonso Rodrigo, MatildeAutoridad UVA Orcid
    Rodríguez Cabello, José CarlosAutoridad UVA Orcid
    Walboomers, X. Frank
    Mata, Álvaro
    Año del Documento
    2014
    Descripción
    Producción Científica
    Documento Fuente
    Biomaterials, 2014, Septiembre, vol. 35 n. 29 p. 8339-47
    Resumen
    In the field of tissue engineering, the properties of the scaffolds are of crucial importance for the success of the application. Hybrid materials combine properties of the different components that constitute them. In this study hybrid gels of elastin-like recombinamer (ELR) and fibrin were prepared with a range on polymer concentrations and ELR-to-fibrin ratios. The correlation between SEM micrographs, porosity, swelling ratio and rheological properties was discussed and a poroelastic mechanism was suggested to explain the mechanical behavior of the hybrid gels. Applicability as scaffold material for cardiovascular tissue engineering was shown by the realization of cell-laden matrixes which supported the synthesis of collagens as revealed by immunohistochemical analysis. As a proof of concept, a tissue-engineered heart valve was fabricated by injection moulding and cultivated in a bioreactor for 3 weeks under dynamic conditions. Tissue analysis revealed production of collagen I and III, fundamental proteins for cardiovascular constructs.
    Materias (normalizadas)
    Ingeniería Química
    ISSN
    0142-9612
    Revisión por pares
    SI
    DOI
    10.1016/j.biomaterials.2014.05.095
    Patrocinador
    Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13)
    Version del Editor
    https://www.sciencedirect.com/science/article/pii/S0142961214006759
    Idioma
    spa
    URI
    http://uvadoc.uva.es/handle/10324/21766
    Derechos
    openAccess
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    • DEP60 - Artículos de revista [112]
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalLa licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 International

    Universidad de Valladolid

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