Show simple item record

dc.contributor.authorRodríguez Cabello, José Carlos 
dc.contributor.authorLi, Yuping
dc.contributor.authorChen, Xi
dc.contributor.authorFok, Alex
dc.contributor.authorAparicio, Conrado
dc.date.accessioned2016-12-16T08:17:33Z
dc.date.available2016-12-16T08:17:33Z
dc.date.issued2015
dc.identifier.citationACS Applied Materials and Interfaces, American Chemical Society, 2015, vol. 7 (46), p. 25784-25792es
dc.identifier.issn1944-8244es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/21788
dc.descriptionProducción Científicaes
dc.description.abstractThe use of insoluble organic matrices as a structural template for the bottom-up fabrication of organic−inorganic nanocomposites is a powerful way to build a variety of advanced materials with defined and controlled morphologies and superior mechanical properties. Calcium phosphate mineralization in polymeric hydrogels is receiving significant attention in terms of obtaining biomimetic hierarchical structures with unique mechanical properties and understanding the mechanisms of the biomineralization process. However, integration of organic matrices with hydroxyapatite nanocrystals, different in morphology and composition, has not been well-achieved yet at nanoscale. In this study, we synthesized thermoresponsive hydrogels, composed of elastin-like recombinamers (ELRs), to template mineralization of hydroxyapatite nanocrystals using a biomimetic polymer-induced liquid-precursor (PILP) mineralization process. Different from conventional mineralization where minerals were deposited on the surface of organic matrices, they were infiltrated into the frameworks of ELR matrices, preserving their microporous structure. After 14 days of mineralization, an average of 78 μm mineralization depth was achieved. Mineral density up to 1.9 g/cm3 was found after 28 days of mineralization, which is comparable to natural bone and dentin. In the dry state, the elastic modulus and hardness of the mineralized hydrogels were 20.3 ± 1.7 and 0.93 ± 0.07 GPa, respectively. After hydration, they were reduced to 4.50 ± 0.55 and 0.10 ± 0.03 GPa, respectively. These values were lower but still on the same order of magnitude as those of natural hard tissues. The results indicated that inorganic−organic hybrid biomaterials with controlled morphologies can be achieved using organic templates of ELRs. Notably, the chemical and physical properties of ELRs can be tuned, which might help elucidate the mechanisms by which living organisms regulate the mineralization process.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherAmerican Chemical Societyes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectFosfatos - Investigaciones químicases
dc.titleBiomimetic Mineralization of Recombinamer-Based Hydrogels toward Controlled Morphologies and High Mineral Densityes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1021/acsami.5b07628es
dc.relation.publisherversionhttp://pubs.acs.org/es
dc.identifier.publicationfirstpage25784es
dc.identifier.publicationissue46es
dc.identifier.publicationlastpage25792es
dc.identifier.publicationtitleACS Applied Materials and Interfaceses
dc.identifier.publicationvolumeVol. 7es
dc.peerreviewedSIes
dc.description.projectJunta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13)es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record