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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/22921

    Título
    Circular Piecewise Regression with an application to cell-cycle gene Biology
    Autor
    Rueda Sabater, María CristinaAutoridad UVA
    Fernández Temprano, Miguel AlejandroAutoridad UVA Orcid
    Barragán, Sandra
    Peddada, Shyamal
    Mardia, Kanti
    Año del Documento
    2016
    Editorial
    Wiley
    Documento Fuente
    Biometrics 72(4), pp 1266-1274
    Résumé
    Applications of circular regression models appear in many different fields such as evolutionary psychology, motor behavior, biology, and, in particular, in the analysis of gene expressions in oscillatory systems. Specifically, for the gene expression problem, a researcher may be interested in modeling the relationship among the phases of cell-cycle genes in two species with differing periods. This challenging problem reduces to the problem of constructing a piecewise circular regression model and, with this objective in mind, we propose a flexible circular regression model which allows different parameter values depending on sectors along the circle. We give a detailed interpretation of the parameters in the model and provide maximum likelihood estimators. We also provide a model selection procedure based on the concept of generalized degrees of freedom. The model is then applied to the analysis of two different cell-cycle data sets and through these examples we highlight the power of our new methodology.
    Revisión por pares
    SI
    DOI
    10.1111/biom.12512
    Patrocinador
    Ministerio de Ciencia e Innovación grant (MTM2012-37129)
    Junta de Castilla y León, Consejería de Educación and the European Social Fund
    Intramural Research Program of the National Institute of Environmental Health Sciences (NIEHS) [Z01 ES101744-04]
    Version del Editor
    http://onlinelibrary.wiley.com/doi/10.1111/biom.12512/abstract;jsessionid=4649BAE88C1AF5513260415AD31B4268.f04t02
    Propietario de los Derechos
    Wiley
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/22921
    Derechos
    openAccess
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalExcepté là où spécifié autrement, la license de ce document est décrite en tant que Attribution-NonCommercial-NoDerivatives 4.0 International

    Universidad de Valladolid

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