Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/24805
Título
Coacervation of Elastin-Like Recombinamer Microgels
Año del Documento
2016
Editorial
Wiley
Descripción
Producción Científica
Documento Fuente
Macromolecular Rapid Communications, 2016, 37, Issue 2, pg.181–186
Resumen
The investigation of the coacervation (self-aggregation) behavior of biomicrogels which can potentially be used as drug carriers is an important topic, because self-aggregation can not only cause loss of activity, but also toxicity and immunogenicity. To study this effect microgels from elastin-like recombinamer are synthesized using miniemulsion technique. The existence of coacervation for such microgels, at different concentrations and temperatures, is studied and proved by cryo-field emission scanning clectron microscopy (cryo-FESEM), cryo-transmission electron microscopy (cryo-TEM), and by a novel 1H high-resolution magic angle sample spinning (HRMAS), nuclear magnetic resonance (NMR) spectroscopy, and relaxometry methods. The findings by 1H HRMAS NMR spectroscopy and relaxometry show simultaneous processes of volume phase temperature transition and coacervation with different sensitivity for hydrophobic and hydrophilic amino acid side-chains in the microgel. The coacervation process is more evidential by the behavior of glycine α-CH2, 1H NMR peak as compared to the proline β-CH2.
Palabras Clave
Microgeles
Revisión por pares
SI
Patrocinador
Ministerio de Industria, Economía y Competitividad (proyectos MAT2013-42473-R y MAT2013-41723-R)
Patrocinador
info:eu-repo/grantAgreement/EC/H2020/642687
Version del Editor
Propietario de los Derechos
WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Idioma
eng
Derechos
openAccess
Aparece en las colecciones
Ficheros en el ítem