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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/25024

    Título
    Calcium signalling in cardiac muscle cells
    Autor
    Withrow, Gil Wier
    López López, José RamónAutoridad UVA Orcid
    Shacklock, Philip S.
    Balke, C. William
    Congreso
    Ciba Foundation Symposium 188
    Año del Documento
    1995
    Editorial
    University of Maryland. School of Medicine
    Descripción Física
    18 p.
    Descripción
    Producción Científica
    Documento Fuente
    Calcium waves, gradients and oscillations. Ciba Foundation Symposium 188. Chichester: Willey, 1995, p.146-164
    Abstract
    In heart cells, severa! distinct kinds of transient spatial patterns of cytoplasmic calcium ion concentration ([ Ca2 + )¡) can be observed: (1) [ Ca2 + )¡ waves, in which regions of spontaneously increased [ Ca2 + ] ; propagate at high velocity (100 ¡.im/s) through the cell; (2) Ca2 + 'sparks', which are spontaneous, non-propagating changes in [ Ca2 + ] ; that are localized in small ( == 2 ¡.im) subcellular regions; and (3) evoked [ Ca2 + )¡ transients that are elicited by electrical depolarization, in association with normal excitation-contraction (E­ C) coupling. In confocal [ Ca2 + ] ¡ images, evoked [ Ca2 + ] ; transients appear to be nearly spatially uniform throughout the cell, except during their rising phase or during small depolarizations. In contrast to [Ca2 + )¡ waves and spontaneous Ca2 + sparks, evoked [ Ca2 + ] ; transients are triggered by L-type Ca2 + channel current and they are 'controlled', in the sense that stopping the L-type Ca2 + current stops them. Despite their different characteristics, ali three types of Ca2 + transient involve Ca2 + -induced release of Ca2 + from the sarcoplasmic reticulum. Here, we address the question of how the autocatalytic process of Ca2 + -induced Ca2 + release, which can easily be understood to underlie spontaneous regenerative ('uncontrolled'), propagating [Ca2 + )¡ waves, might be 'harnessed', under other circumstances, to produce controlled changes in [ Ca2 + ]¡, as during normal excitation-contraction coupling, or changes in [ Ca2 + )¡ that do not propagate. We discuss our observations of Ca2 + waves, Ca2 + sparks and normal Ca2 + transients in heart cells and review our results on the 'gain' of Ca2 + -induced Ca2 + release. We discuss a model involving Ca2 + microdomains beneath L-type Ca2 + channels, and clusters of Ca2 + -activated Ca2 + release channels in the sarcoplasmic reticulum which may form the basis of the answer to this question
    Palabras Clave
    Células cardíacas
    Calcio
    Version del Editor
    https://onlinelibrary.wiley.com/doi/10.1002/9780470514696.ch9
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/25024
    Derechos
    openAccess
    Aparece en las colecciones
    • IBGM - Comunicaciones a congresos, conferencias, etc. [1]
    • VASCUMIT - Comunicaciones a congresos, conferencias, etc. [1]
    • DEP06 - Comunicaciones a congresos, conferencias, etc. [5]
    Mostra tutti i dati dell'item

    Universidad de Valladolid

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