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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/25814

    Título
    Determination of homogentisic acid using HPLC with amperometric detection at carbon paste electrodes
    Autor
    Lozano Alonso, María
    Director o Tutor
    Vega Alegre, María del SolAutoridad UVA
    Dejmková, Hana
    Editor
    Universidad de Valladolid. Facultad de CienciasAutoridad UVA
    Año del Documento
    2017
    Titulación
    Grado en Química
    Resumo
    Homogentisic acid is an intermediate of the metabolic breakdown of tyrosine and phenylalanine; its accumulation in body fluids suggests the break in the metabolic pathway of these compounds and related health-threatening complications. In our work, a determination method for this compound was developed using HPLC with amperometric detection on glassy carbon paste electrode. Optimum conditions were found, considering both electrode response and chromatographic parameters. Separation was performed on Kromasil 100 C18, 250 x 4.6 mm (5 μm) column using gradient elution; mobile phase consisted of acidic buffer and methanol, with methanol content changing from 5% to 30% in 10 min. Repeatability of the measurements and linearity of the electrode response were confirmed. Applicability of the method was proved by the determination in spiked urine samples.
    Palabras Clave
    Homogentisic acid
    Alkaptonuria
    HPLC
    Amperometric detection
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/25814
    Derechos
    openAccess
    Aparece en las colecciones
    • Trabajos Fin de Grado UVa [30971]
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    TFG-G2428.pdf
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    Universidad de Valladolid

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