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dc.contributor.authorInfante Blanco, Rebeca
dc.contributor.authorMartín Álvarez, José Miguel 
dc.contributor.authorAndrés Juan, Celia 
dc.contributor.authorNieto Román, Francisco Javier 
dc.date.accessioned2018-03-12T12:08:35Z
dc.date.available2018-07-07T23:40:44Z
dc.date.issued2017
dc.identifier.citationOrganic Letters, 2017, 19 (7), pp 1516–1519es
dc.identifier.issn1523-7060es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/28951
dc.descriptionProducción Científicaes
dc.description.abstractAn efficient enantioselective Me2Zn-mediated mono addition of phenylacetylene to α-diketones in the presence of a chiral perhydro-1,3-benzoxazine ligand is described. At temperatures higher than -20 ºC a kinetic resolution of the resulting α-hydroxy ketone occurs which greatly improves the enantioselectivity although with moderate chemical yield. The alkynylation of nonsymmetrical aromatic diketones with electronically different substituents on the aromatic rings proceed with high regioselectivity. This procedure allows the preparation of α-hydroxy-α-ynyl-ketones as highly enantioenriched materials.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherAmerican Chemical Societyes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleDimethylzinc-Mediated Addition of Phenylacetylene to α-Diketones Catalyzed by Chiral Perhydro-1,3-benzoxazineses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1021/acs.orglett.7b00252es
dc.relation.publisherversionhttps://pubs.acs.org/doi/abs/10.1021/acs.orglett.7b00252es
dc.peerreviewedSIes
dc.description.embargo2018-07-07es
dc.description.projectMinisterio de Economía, Industria y Competitividad (Project CTQ2014-59870 P)es
dc.description.projectJunta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA064U13)es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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