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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/29173

    Título
    A Role for DPPX Modulating External TEA Sensitivity of Kv4 Channels
    Autor
    López López, José RamónAutoridad UVA Orcid
    Colinas, Olaia
    Pérez Carretero, Francisco D.
    Pérez García, María TeresaAutoridad UVA Orcid
    Año del Documento
    2008
    Editorial
    Rockefeller University Press
    Descripción
    Producción Científica
    Documento Fuente
    The Journal of General Physiology, April 2008, vol. 131, n. 5. p. 455-471
    Résumé
    Shal-type (Kv4) channels are expressed in a large variety of tissues, where they contribute to transient voltage- dependent K+ currents. Kv4 are the molecular correlate of the A-type current of neurons (ISA), the fast component of ITO current in the heart, and also of the oxygen-sensitive K+ current (KO2) in rabbit carotid body (CB) chemore- ceptor cells. The enormous degree of variability in the physiological properties of Kv4-mediated currents can be attributable to the complexity of their regulation together with the large number of ancillary subunits and scaffold- ing proteins that associate with Kv4 proteins to modify their trafficking and their kinetic properties. Among those, KChIPs and DPPX proteins have been demonstrated to be integral components of ISA and ITO currents, as their co- expression with Kv4 subunits recapitulates the kinetics of native currents. Here, we explore the presence and func- tional contribution of DPPX to KO2 currents in rabbit CB chemoreceptor cells by using DPPX functional knockdown with siRNA. Additionally, we investigate if the presence of DPPX endows Kv4 channels with new pharmacological properties, as we have observed anomalous tetraethylammonium (TEA) sensitivity in the native KO2 currents. DPPX association with Kv4 channels induced an increased TEA sensitivity both in heterologous expression systems and in CB chemoreceptor cells. Moreover, TEA application to Kv4-DPPX heteromultimers leads to marked kinetic ef- fects that could be explained by an augmented closed-state inactivation. Our data suggest that DPPX proteins are integral components of KO2 currents, and that their association with Kv4 subunits modulate the pharmacological profile of the heteromultimers.
    Materias (normalizadas)
    Neurofisiología
    ISSN
    0022-1295
    Revisión por pares
    SI
    DOI
    10.1085/jgp.200709912
    Patrocinador
    Este trabajo ha sido financiado por el Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III , Ministerio de Educación y Ciencia and Junta de Castilla y León.
    Version del Editor
    http://jgp.rupress.org/content/131/5/455
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/29173
    Derechos
    openAccess
    Aparece en las colecciones
    • IBGM - Artículos de revista [78]
    • VASCUMIT - Artículos de revista [47]
    • DEP06 - Artículos de revista [352]
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    PD-386.pdf
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalExcepté là où spécifié autrement, la license de ce document est décrite en tant que Attribution-NonCommercial-NoDerivatives 4.0 International

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