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dc.contributor.authorGonzález Fajardo, José Antonio
dc.contributor.authorArreba, Emilio
dc.contributor.authorCastrodeza Sanz, José Javier 
dc.contributor.authorPérez Castrillon, José Luis 
dc.contributor.authorFernández, Leopoldo
dc.contributor.authorAgundez, Ignacio
dc.contributor.authorMateo, Antonio M.
dc.contributor.authorCarrera, Santiago
dc.contributor.authorGutíerrez Alonso, Vicente
dc.contributor.authorVaquero Puerta, Carlos 
dc.date.accessioned2013-09-18T10:19:09Z
dc.date.available2013-09-18T10:19:09Z
dc.date.issued1999
dc.identifier.citationJournal of Vascular Surgery, August, vol.30, n.2. p.283-292es
dc.identifier.issn0741-5214es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/3443
dc.descriptionProducción Científicaes
dc.description.abstractPurpose: The primary objective of this study was to evaluate with venography the rate of thrombus regression after a fixed dose of low–molecular weight heparin (LMWH) per day for 3 months compared with oral anticoagulant therapy for deep venous thrombosis (DVT). Secondary endpoints were the comparisons of the efficacy and safety of both treatments. Methods: This study was designed as an open randomized clinical study in a university hospital setting. Of the 165 patients finally enrolled in the study, 85 were assigned LMWH therapy and 80 were assigned oral anticoagulant therapy. In the group randomized to oral anticoagulant therapy, the patients first underwent treatment in the hospital with standard unfractionated heparin and then coumarin for 3 months. Doses were adjusted with laboratory monitoring to maintain the international normalized ratio between 2.0 and 3.0. Patients in the LMWH group were administered subcutaneous injections of fixed doses of 40 mg enoxaparin (4000 anti-Xa units) every 12 hours for 7 days, and after discharge from the hospital, they were administered 40 mg enoxaparin once daily at fixed doses for 3 months without a laboratory control assay. A quantitative venographic score (Marder score) was used to assess the extent of the venous thrombosis, with 0 points indicating no DVT and 40 points indicating total occlusion of all deep veins. The rate of thrombus reduction was defined as the difference in quantitative venographic scores after termination of LMWH or coumarin therapy as compared with the scores obtained on the initial venographic results. The efficacy was defined as the ability to prevent symptomatic extension or recurrence of venous thromboembolism (documented with venograms or serial lung scans). The safety was defined as the occurrence of hemorrhages. Results: After 3 months of treatment, the mean Marder score was significantly decreased in both groups in comparison with the baseline score, although the effect of therapy was significantly better after LMWH therapy (49.4% reduction) than after coumarin therapy (24.5% reduction; P < .001). LMWH therapy and male gender were independently associated with an enhanced resolution of the thrombus. A lower frequency of symptomatic recurrent venous thromboembolism was also shown in patients who underwent treatment with LMWH therapy (9.5%) than with oral anticoagulant therapy (23.7%; P < .05), although this difference was entirely a result of recurrence of DVT. Bleeding complications were significantly fewer in the LMWH group than in the coumarin group (1.1% vs 10%; P < .05). This difference was caused by minor hemorrhages. Coumarin therapy and cancer were independently associated with an enhanced risk of complications. Subcutaneous heparin therapy was well tolerated by all patients. Conclusion: The patients who were allocated to undergo enoxaparin therapy had a significantly greater improvement in their quantitative venographic score, a significantlyes
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subjectTrombosis-Tratamientoes
dc.titleVenographic comparison of subcutaneous low-molecular weight heparin with oral anticoagulant therapy in the long-term treatment of deep venous thrombosises
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doihttps://doi.org/10.1016/S0741-5214(99)70139-4es
dc.identifier.publicationfirstpage283es
dc.identifier.publicationissue2es
dc.identifier.publicationlastpage292es
dc.identifier.publicationtitleJournal of Vascular Surgeryes
dc.identifier.publicationvolume30es
dc.peerreviewedSIes
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported


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