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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/35328

    Título
    Genetically Engineered Elastin-based Biomaterials for Biomedical Applications
    Autor
    Santos García, María MercedesAutoridad UVA Orcid
    Serrano Dúcar, Sofía
    González Valdivieso, JuanAutoridad UVA Orcid
    Vallejo Vicente, Reinaldo
    Girotti ., AlessandraAutoridad UVA Orcid
    Cuadrado Curto, María PurificaciónAutoridad UVA Orcid
    Arias Vallejo, Francisco JavierAutoridad UVA Orcid
    Año del Documento
    2018
    Editorial
    Benthan Science
    Descripción
    Producción Científica
    Documento Fuente
    Current Medicinal Chemistry, 2018. 25 p.
    Resumo
    Protein-based polymers are some of the most promising candidates for a new generation of innovative biomaterials as recent advances in genetic-engineering and biotechnological techniques mean that protein-based biomaterials can be designed and constructed with a high degree of complexity and accuracy. Moreover, their sequences, which are derived from structural protein-based modules, can easily be modified to include bioactive motifs that improve their functions and material-host interactions, thereby satisfying fundamental biological requirements. The accuracy with which these advanced polypeptides can be produced, and their versatility, self-assembly behavior, stimuli-responsiveness and biocompatibility, means that they have attracted increasing attention for use in biomedical applications such as cell culture, tissue engineering, protein purification, surface engineering and controlled drug delivery. The biopolymers discussed in this review are elastin-derived protein-based polymers which are biologically inspired and biomimetic materials. This review will also focus on the design, synthesis and characterization of these genetically encoded polymers and their potential utility for controlled drug and gene delivery, as well as in tissue engineering and regenerative medicine.
    Palabras Clave
    Biomateriales
    Biomaterials
    Elastina
    Elastin
    Ingeniería genética
    Genetic engineering
    Aplicaciones biomédicas
    Biomedical Applications
    ISSN
    0929-8673
    Revisión por pares
    SI
    DOI
    10.2174/0929867325666180508094637
    Patrocinador
    European Social Fund (ESF) and European Regional Development Fund (ERDF)
    EU (NMP-2014-646075, HEALTH-F4-2011-278557, PITN-GA-2012-317306 and MSCA-ITN-2014-642687)
    Ministerio de Economía, Industria y Competitividad (Projects MAT2015-68901-R, MAT2016-79435-R and MAT2016-78903-R)
    Junta de Castilla y León (programa de apoyo a proyectos de investigación - Ref. Projects VA244U13 and VA313U14)
    Version del Editor
    http://www.eurekaselect.com/161911/article
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/35328
    Derechos
    openAccess
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    • BIOFORGE - Artículos de revista [89]
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    Genetically engineered elastin-based biomaterials .pdf
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalExceto quando indicado o contrário, a licença deste item é descrito como Attribution-NonCommercial-NoDerivatives 4.0 International

    Universidad de Valladolid

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