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dc.contributor.authorRodríguez Ferrer, Patricia
dc.contributor.authorSanz Novo, Miguel 
dc.contributor.authorMaestro Fernández, Alicia 
dc.contributor.authorAndrés García, José María 
dc.contributor.authorPedrosa Sáez, Rafael 
dc.date.accessioned2019-08-30T09:06:30Z
dc.date.available2019-08-30T09:06:30Z
dc.date.issued2019
dc.identifier.citationAdvanced Synthesis and Catalysis, 2019, vol. 361, n. 15. p. 3645-3655es
dc.identifier.issn1615-4169es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/37719
dc.descriptionProducción Científicaes
dc.description.abstractEnantioenriched 3‐amino‐3‐substituted oxindoles have been obtained by addition of different nucleophiles to N‐Boc ketimines derived from isatin catalyzed by chiral bifunctional supported thioureas. The Mannich reaction occurs with excellent enantioselection, but poor diastereoselection when prochiral nucleophiles were used. The supported catalyst were recovered and reused for five times without loss of activity. The mixture of diastereoisomers formed when a prochiral structure was used as nucleophile was converted into a single enantioenriched pyrazolyl derivative.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherWiley Online Libraryes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.classificationCatálisis asimétricaes
dc.subject.classificationAsymmetric catalysises
dc.subject.classification3-Amino-oxindoleses
dc.subject.classification3-Amino-oxindoleses
dc.subject.classificationPirazoles quiraleses
dc.subject.classificationChiral pyrazoleses
dc.subject.classificationTioureas bifuncionaleses
dc.subject.classificationBifunctional thioureases
dc.subject.classificationReacción de Manniches
dc.subject.classificationMannich reactiones
dc.titleSynthesis of Enantioenriched 3-Amino-3-Substituted Oxindoles by Stereoselective Mannich Reaction Catalyzed by Supported Bifunctional Thioureases
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2019 Wiley-VCHes
dc.identifier.doihttps://doi.org/10.1002/adsc.201900414es
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1002/adsc.201900414es
dc.peerreviewedSIes
dc.description.projectMinisterio de Economía, Industria y Competitividad (Project FEDER-CTQ2014–59870-P)es
dc.description.projectJunta de Castilla y León (Projects FEDER-VA115P17 / VA149G18)es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersiones


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