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dc.contributor.authorTejero del Río, Jesús
dc.contributor.authorJiménez López, María del Pilar 
dc.contributor.authorQuinto Fernández, Emiliano José 
dc.contributor.authorCordoba Diaz, Damián
dc.contributor.authorGarrosa García, Manuel 
dc.contributor.authorCordoba Diaz, Manuel
dc.contributor.authorGayoso Rodríguez, Manuel José 
dc.contributor.authorGirbés Juan, Tomás 
dc.date.accessioned2020-06-04T13:01:18Z
dc.date.available2020-06-04T13:01:18Z
dc.date.issued2015
dc.identifier.citationMolecules, 2015, vol. 20, n. 2. p. 2364-2387es
dc.identifier.issn1420-3049es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/40992
dc.descriptionProducción Científicaes
dc.description.abstractSambucus (Adoxaceae) species have been used for both food and medicine purposes. Among these, Sambucus nigra L. (black elder), Sambucus ebulus L. (dwarf elder), and Sambucus sieboldiana L. are the most relevant species studied. Their use has been somewhat restricted due to the presence of bioactive proteins or/and low molecular weight compounds whose ingestion could trigger deleterious effects. Over the last few years, the chemical and pharmacological characteristics of Sambucus species have been investigated. Among the proteins present in Sambucus species both type 1, and type 2 ribosome-inactivating proteins (RIPs), and hololectins have been reported. The biological role played by these proteins remains unknown, although they are conjectured to be involved in defending plants against insect predators and viruses. These proteins might have an important impact on the nutritional characteristics and food safety of elderberries. Type 2 RIPs are able to interact with gut cells of insects and mammals triggering a number of specific and mostly unknown cell signals in the gut mucosa that could significantly affect animal physiology. In this paper, we describe all known RIPs that have been isolated to date from Sambucus species, and comment on their antiviral and entomotoxic effects, as well as their potential uses.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.classificationDwarf elderes
dc.subject.classificationSaúco menores
dc.subject.classificationBlack elderes
dc.subject.classificationSaúco negroes
dc.subject.classificationEbulines
dc.subject.classificationEbulinaes
dc.subject.classificationImmunotoxinses
dc.subject.classificationInmunotoxinases
dc.titleElderberries: A source of ribosome-inactivating proteins with lectin activityes
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2015 MDPIes
dc.identifier.doi10.3390/molecules20022364es
dc.relation.publisherversionhttps://www.mdpi.com/1420-3049/20/2/2364es
dc.peerreviewedSIes
dc.description.projectJunta de Castilla y León (Grupo de Excelencia GR106)es
dc.description.projectUniversidad Complutense de Madrid (research group 950247)es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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