Autoantibodies against MHC class I polypeptide-related sequence A are associated with increased risk of concomitant autoimmune diseases in celiac patients

López Vázquez, Antonio; Mozo, Lourdes; Alonso Arias, Rebeca; Suárez Álvarez, Beatriz; Vidal Castiñeira, José Ramón; Arranz Sanz, Eduardo; Volta, Umberto; Bousoño, Carlos; López Hoyos, Marcos; Rodrigo, Luis; López Larrea, Carlos

doi:10.1186/1741-7015-12-34

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Título

Autoantibodies against MHC class I polypeptide-related sequence A are associated with increased risk of concomitant autoimmune diseases in celiac patients

Autor

López Vázquez, Antonio

Mozo, Lourdes

Alonso Arias, Rebeca

Suárez Álvarez, Beatriz

Vidal Castiñeira, José Ramón

Año del Documento

2014

Editorial

Bio Med Central (BMC)

Descripción

Producción Científica

Documento Fuente

BMC Medicine, 2014, volume 12, n. 1, Article number 34

Résumé

Overexpression of autologous proteins can lead to the formation of autoantibodies and autoimmune diseases. MHC class I polypeptide-related sequence A (MICA) is highly expressed in the enterocytes of patients with celiac disease, which arises in response to gluten. The aim of this study was to investigate anti-MICA antibody formation in patients with celiac disease and its association with other autoimmune processes.

Materias Unesco

3205 Medicina Interna

Palabras Clave

Anticuerpos

Enfermedad celíaca

ISSN

1741-7015

Revisión por pares

DOI

10.1186/1741-7015-12-34

Patrocinador

Instituto de Salud Carlos III, RETICS REDiNREN (RD12/0021/0021)