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    Título
    Ascorbate-dependent decrease of the mucosal immune inflammatory response to gliadin in coeliac disease patients
    Autor
    Bernardo Ordiz, DavidAutoridad UVA Orcid
    Martínez Abad, Beatriz
    Vallejo Diez, Sara
    Montalvillo Álvarez, EnriqueAutoridad UVA
    Benito, V.
    Anta, B.
    Fernández Salazar, Luis IgnacioAutoridad UVA
    Garrote Adrados, José AntonioAutoridad UVA Orcid
    Año del Documento
    2012
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    Allergol. Immunopathol. (Madr.) 2012, vol. 40, n. 1. p.3-8
    Résumé
    Background: The IL-15/NF- B axis has an important role in coeliac disease (CD) and may represent a molecular target for immunomodulation. Ascorbate (vitamin C) is known to show inhibitory effects on NF- B. Therefore, we studied if ascorbate supplementation to gliadin gliadin-stimulated biopsy culture could down-regulate the mucosal immune response to gliadin in CD. Methods: Duodenal biopsy explants from treated CD patients were gliadin challenged in vitro (100 g/ml) with and without 20 mM ascorbate. An extra tissue explant in basal culture was used as internal control. Secretion levels of nitrites (3 h), and IFN , TNF , IFN , IL-17, IL-13, and IL-6 (24 h) were measured on the supernatants. IL-15 was assayed by western-blot on whole protein duodenal explants. Results: The addition of ascorbate to in vitro culture gliadin-challenged biopsies blocked the secretion of nitrites (p = 0.013), IFN (p = 0.0207), TNF (p = 0.0099), IFN (p = 0.0375), and IL-6 (p = 0.0036) compared to samples from non-ascorbate supplemented culture. Cytokine secretion was downregulated by ascorbate even to lower values than those observed in basal cultures (IFN : p = 0.0312; TNF : p = 0.0312; IFN : p = 0.0312; and IL-6: p = 0.0078). Gliadinchallenge induced IL-15 production in biopsies from treated CD patients, while the addition of ascorbate to culture medium completely inhibited IL-15 production. Moreover, the inhibition of IL-15 by ascorbate took place even in the only treated CD-patient who had basal IL-15 production. Conclusions: Ascorbate decreases the mucosal inflammatory response to gluten in an intestinal biopsy culture model, so it might have a role in future supplementary therapy in CD. © 2010 SEICAP. Published by Elsevier España, S.L. All rights reserve
    Materias (normalizadas)
    Enfermedad celíaca
    ISSN
    0301-0546
    Revisión por pares
    SI
    Propietario de los Derechos
    Elsevier-Doyma
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/4201
    Derechos
    openAccess
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    • DEP55 - Artículos de revista [206]
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