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dc.contributor.author | León, Alberto José | |
dc.contributor.author | Garrote Adrados, José Antonio | |
dc.contributor.author | Blanco Quirós, Alfredo | |
dc.contributor.author | Calvo Romero, María del Carmen | |
dc.contributor.author | Fernández Salazar, Luis Ignacio | |
dc.contributor.author | Villar, A. del | |
dc.contributor.author | Barrera, Asterio | |
dc.contributor.author | Arranz Sanz, Eduardo | |
dc.date.accessioned | 2014-01-29T08:57:42Z | |
dc.date.available | 2014-01-29T08:57:42Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Clinical and Experimental Immunology, 146: 479-485 | es |
dc.identifier.issn | 0009-9104 | es |
dc.identifier.uri | http://uvadoc.uva.es/handle/10324/4202 | |
dc.description | Producción Científica | es |
dc.description.abstract | Dietary gluten induces an early response in the intestine of coeliac disease patients (CD), within a few hours, and this is driven by high levels of proinflammatory cytokines, including IFNg and IL-15, as has been thoroughly shown by gluten stimulation of biopsy explants. Our aim was to identify the immune mediators involved in the long-standing inflammation in untreated CD patients at diagnosis. mRNA and protein levels of TNFa, IL-12(p35), IL-12(p40), IL-15, IL-18 and IL-23(p19) were quantified in biopsies from active CD patients, CD patients on a gluten-free diet (GFD), healthy controls, and patients with non-CD inflammation and mild histological changes in the intestine. Biopsies from CD patients on a GFD were also stimulated in vitro with gliadin, and protein expression of IL-15 and IL-18 was analysed. Levels of IL-12 and IL-23 mRNA are nearly absent, and TNFa levels remain unchanged among different groups. Both the active and inactive forms of IL-18 protein have been found in all samples from active CD, and protein expression was only localized within the crypts. Levels of IL-15 mRNA remain unchanged, and protein expression, localized within the lamina propria, is found in a small number of samples. In vitro stimulation with gluten induces the expression of IL-15 and IL-18. In active CD, the early response following gluten intake characterized by high IFNg levels is driven by IL-18, and probably IL-15, and this alternates with periods of long-standing inflammation with moderate IFNg levels, maintained by IL-18 alone. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | British Society for Immunology | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Enfermedad celíaca | es |
dc.subject | Intestinos - Enfermedades | es |
dc.title | Interleukin 18 maintains a long-standing inflammation in coeliac disease patients | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | British Society for Immunology | es |
dc.identifier.doi | 10.111/j.1365-2249.2006.03239.X | es |
dc.identifier.publicationfirstpage | 479 | es |
dc.identifier.publicationissue | 146 | es |
dc.identifier.publicationlastpage | 485 | es |
dc.identifier.publicationtitle | Clinical and Experimental Immunology | es |
dc.peerreviewed | SI | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
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