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    Título
    Genes associated with metabolic syndrome predict disease-free survival in stage II colorectal cancer patients. A novel link between metabolic dysregulation and colorectal cancer
    Autor
    Vargas, Teodoro
    Moreno Rubio, Juan
    Herranz, Jesús
    Cejas, Paloma
    Molina, Susana
    González-Vallinas Garrachón, MargaritaAutoridad UVA
    Ramos, Ricardo
    Burgos, Emilio
    Aguayo, Cristina
    Custodio, Ana B.
    Reglero, Guillermo
    Feliu, Jaime
    Ramírez de Molina, Ana
    Año del Documento
    2014
    Editorial
    Wiley Open Access
    Descripción
    Producción Científica
    Documento Fuente
    Molecular Oncology, 2014, vol. 8, n. 8, p.1469-1481
    Resumen
    Studies have recently suggested that metabolic syndrome and its components increase the risk of colorectal cancer. Both diseases are increasing in most countries, and the genetic association between them has not been fully elucidated. The objective of this study was to assess the association between genetic risk factors of metabolic syndrome or related conditions (obesity, hyperlipidaemia, diabetes mellitus type 2) and clinical outcome in stage II colorectal cancer patients. Expression levels of several genes related to metabolic syndrome and associated alterations were analysed by real-time qPCR in two equivalent but independent sets of stage II colorectal cancer patients. Using logistic regression models and cross-validation analysis with all tumour samples, we developed a metabolic syndrome-related gene expression profile to predict clinical outcome in stage II colorectal cancer patients. The results showed that a gene expression profile constituted by genes previously related to metabolic syndrome was significantly associated with clinical outcome of stage II colorectal cancer patients. This metabolic profile was able to identify patients with a low risk and high risk of relapse. Its predictive value was validated using an independent set of stage II colorectal cancer patients. The identification of a set of genes related to metabolic syndrome that predict survival in intermediate-stage colorectal cancer patients allows delineation of a high-risk group that may benefit from adjuvant therapy and avoid the toxic and unnecessary chemotherapy in patients classified as low risk. Our results also confirm the linkage between.
    Materias Unesco
    3207.13 Oncología
    Palabras Clave
    Cáncer colorrectal
    Síndrome metabólico
    Apolipoproteínas
    Biomarcador de pronóstico
    ISSN
    1574-7891
    Revisión por pares
    SI
    DOI
    10.1016/j.molonc.2014.05.015
    Patrocinador
    Ministerio de Ciencia, Innovación y Universidades (AGL2010-21565, RyC 2008-03734, IPT-2011-1248-060000),y la Comunidad de Madrid (ALIBIRD, S2009/AGR-1469)
    Version del Editor
    https://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.molonc.2014.05.015
    Propietario de los Derechos
    © Wiley Open Access
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/42589
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP06 - Artículos de revista [352]
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