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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/44469

    Título
    Association of circulating microRNAs with coronary artery disease and usefulness for reclassification of healthy individuals: The REGICOR study
    Autor
    Dégano, Irene R.
    Camps Vilaró, Anna
    Subirana, Isaac
    García Mateo, Nadia
    Cidad Velasco, María Del PilarAutoridad UVA Orcid
    Muñoz Aguayo, Daniel
    Puigdecanet, Eulàlia
    Nonell, Lara
    Vila, Joan
    Crepaldi, Felipe M.
    Gonzalo Calvo, David de
    Llorente Cortés, Vicenta
    Pérez García, María TeresaAutoridad UVA Orcid
    Elosua, Roberto
    Fitó, Montserrat
    Marrugat, Jaume
    Año del Documento
    2020
    Editorial
    MPDI
    Descripción
    Producción Científica
    Documento Fuente
    Journal of Clinical Medicine, 2020, vol. 9, n. 5. 14 p.
    Abstract
    Risk prediction tools cannot identify most individuals at high coronary artery disease (CAD) risk. Oxidized low-density lipoproteins (oxLDLs) and microRNAs are actively involved in atherosclerosis. Our aim was to examine the association of CAD and oxLDLs-induced microRNAs, and to assess the microRNAs predictive capacity of future CAD events. Human endothelial and vascular smooth muscle cells were treated with oxidized/native low-density lipoproteins, and microRNA expression was analyzed. Differentially expressed and CAD-related miRNAs were examined in serum samples from (1) a case-control study with 476 myocardial infarction (MI) patients and 487 controls, and (2) a case-cohort study with 105 incident CAD cases and 455 randomly-selected cohort participants. MicroRNA expression was analyzed with custom OpenArray plates, log rank tests and Cox regression models. Twenty-one microRNAs, two previously undescribed (hsa-miR-193b-5p and hsa-miR-1229-5p), were up- or down-regulated upon cell treatment with oxLDLs. One of the 21, hsa-miR-122-5p, was also upregulated in MI cases (fold change = 4.85). Of the 28 CAD-related microRNAs tested, 11 were upregulated in MI cases-1 previously undescribed (hsa-miR-16-5p)-, and 1/11 was also associated with CAD incidence (adjusted hazard ratio = 0.55 (0.35–0.88)) and improved CAD risk reclassification, hsa-miR-143-3p. We identified 2 novel microRNAs modulated by oxLDLs in endothelial cells, 1 novel microRNA upregulated in AMI cases compared to controls, and one circulating microRNA that improved CAD risk classification.
    Materias (normalizadas)
    Arterias coronarias - Enfermedades
    Materias Unesco
    3205.01 Cardiología
    Palabras Clave
    Lipoproteins
    Lipoproteínas
    MicroRNAs
    MicroARNs
    Myocardial infarction
    Infarto de miocardio
    ISSN
    2077-0383
    Revisión por pares
    SI
    DOI
    10.3390/jcm9051402
    Patrocinador
    Fondo Europeo de Desarrollo Regional (projects FIS-CP12/03287, FIS-14/00449, FIS-PI081327, INTRASALUD PI11/01801, PI15/00064, IJCI-2016-29393 to DdG-C, CIBERCV (CB16/11/00229, 00246, 00403), CIBERESP CB06/02/0029 and CIBEROBN CB06/03/0028)
    Ministerio de Economía, Industria y Competitividad (project BFU2016-75360-R)
    Fundación BBVA (project PR-16-BIO-CAR-0041)
    Departament de Salut de la Generalitat de Catalunya - Agència de Gestió d’Ajuts Universitaris de Recerca de Catalunya (project 2017SGR222)
    Pla estratègic de recerca i innovació en salut (project SLT006/17/00234, SLT002/16/00145 and SLT006/17/00029)
    Junta de Castilla y León (project VA114P17)
    Version del Editor
    https://www.mdpi.com/2077-0383/9/5/1402
    Propietario de los Derechos
    © 2020 MDPI
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/44469
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Collections
    • VASCUMIT - Artículos de revista [47]
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    Attribution-NonCommercial-NoDerivatives 4.0 InternacionalExcept where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internacional

    Universidad de Valladolid

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