Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice

Villa Pérez, Pablo; Merino Antolín, Beatriz; Fernández Díaz, Cristina María; Cidad Velasco, María Del Pilar; Domínguez Lobatón, María Carmen; Moreno Díaz-Calderón, Alfredo; Muturi, Harrison T.; Ghadieh, Hilda E.; Leissring, Malcolm A.; Cózar Castellano, Irene; Perdomo Hernández, Germán

doi:10.1016/j.metabol.2018.08.001

Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/44474

Título

Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice

Año del Documento

2018

Editorial

Elsevier

Descripción

Producción Científica

Documento Fuente

Metabolism, 2018, vol. 88. p. 1-11

Resumen

The role of insulin-degrading enzyme (IDE), a metalloprotease with high affinity for insulin, in insulin clearance remains poorly understood. OBJECTIVE: This study aimed to clarify whether IDE is a major mediator of insulin clearance, and to define its role in the etiology of hepatic insulin resistance.

Palabras Clave

Insulin-degrading enzymes

Encimas degradadoras de insulina

Insulin receptors

Receptores de insulina

ISSN

0026-0495

Revisión por pares

DOI

10.1016/j.metabol.2018.08.001

Patrocinador

Ministerio de Economía, Industria y Competitividad (projects AF2014-58702-C2-1-R, SAF2016-77871-C2-1-R, SAF2014-58702-C2-2-R and SAF2016-77871-C2-2-R)
National Institutes of Health (projects R01-DK054254, R01-DK083850, RO1-HL-112248 and R01-GM115617)
American Diabetes Association (Career Development Award 7-11-CD-13 t)

Version del Editor

https://www.sciencedirect.com/science/article/pii/S0026049518301690?via%3Dihub