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    Título
    Contribution of Kv channels to phenotypic remodeling of human uterine artery smooth muscle cells
    Autor
    Miguel Velado, Eduardo
    Moreno Domínguez, Alejandro
    Colinas, Olaia
    Cidad Velasco, María Del PilarAutoridad UVA Orcid
    Heras i Fortuny, Maria Magdalena
    Pérez García, María TeresaAutoridad UVA Orcid
    López López, José RamónAutoridad UVA Orcid
    Año del Documento
    2005
    Editorial
    American Heart Association
    Descripción
    Producción Científica
    Documento Fuente
    Circulation Research, 2005, vol. 97, n. 12. p. 1280-1287
    Résumé
    Vascular smooth muscle cells (VSMCs) perform diverse functions that can be classified into contractile and synthetic (or proliferating). All of these functions can be fulfilled by the same cell because of its capacity of phenotypic modulation in response to environmental changes. The resting membrane potential is a key determinant for both contractile and proliferating functions. Here, we have explored the expression of voltage-dependent K+ (Kv) channels in contractile (freshly dissociated) and proliferating (cultured) VSMCs obtained from human uterine arteries to establish their contribution to the functional properties of the cells and their possible participation in the phenotypic switch. We have studied the expression pattern (both at the mRNA and at the protein level) of Kvα subunits in both preparations as well as their functional contribution to the K+ currents of VSMCs. Our results indicate that phenotypic remodeling associates with a change in the expression and distribution of Kv channels. Whereas Kv currents in contractile VSMCs are mainly performed by Kv1 channels, Kv3.4 is the principal contributor to K+ currents in cultured VSMCs. Furthermore, selective blockade of Kv3.4 channels resulted in a reduced proliferation rate, suggesting a link between Kv channels expression and phenotypic remodeling.
    Palabras Clave
    Potassium channels
    Canales de potasio
    Vascular smooth muscle
    Músculo liso vascular
    Cell proliferation
    Proliferación celular
    ISSN
    1524-4571
    Revisión por pares
    SI
    DOI
    10.1161/01.RES.0000194322.91255.13
    Patrocinador
    Ministerio de Sanidad, Consumo y Bienestar Social - Instituto de Salud Carlos III (grants R006/009. FS041139-0 and PI041044)
    Ministerio de Ciencia, Innovación y Universidades (grants BFU2004-05551 and BFU2007-61524)
    Junta de Castilla y León (grant GR242)
    Version del Editor
    https://www.ahajournals.org/doi/10.1161/01.RES.0000194322.91255.13
    Propietario de los Derechos
    © 2005 American Heart Association
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/44600
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP06 - Artículos de revista [352]
    • IBGM - Artículos de revista [78]
    • VASCUMIT - Artículos de revista [47]
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    Contribution-of-Kvchannels.pdf
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    Attribution-NonCommercial-NoDerivs 3.0 UnportedExcepté là où spécifié autrement, la license de ce document est décrite en tant que Attribution-NonCommercial-NoDerivs 3.0 Unported

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