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    • Dpto. Biología Celular, Genética, Histología y Farmacología
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    • DEP05 - Artículos de revista
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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/45227

    Título
    Assessment of the corneal collagen organization after chemical burn using second harmonic generation microscopy
    Autor
    Bueno, Juan M.
    Ávila, Francisco J.
    Lorenzo Martín, ElviraAutoridad UVA
    Gallego Muñoz, PatriciaAutoridad UVA Orcid
    Martínez García, María del CarmenAutoridad UVA Orcid
    Año del Documento
    2021
    Editorial
    Optical Society of America (OSA)
    Descripción
    Producción Científica
    Documento Fuente
    Biomedical Optics Express Vol. 12, Issue 2, pp. 756-765 (2021)
    Zusammenfassung
    The organization of the corneal stoma is modified due to different factors, including pathology, surgery or external damage. Here the changes in the organization of the corneal collagen fibers during natural healing after chemical burn are investigated using second harmonic generation (SHG) imaging. Moreover, the structure tensor (ST) was used as an objective tool for morphological analyses at different time points after burn (up to 6 months). Unlike control corneas that showed a regular distribution, the collagen pattern at 1 month of burn presented a non-organized arrangement. SHG signal levels noticeably decreased and individual fibers were hardly visible. Over time, the healing process led to a progressive re-organization of the fibers that could be quantified through the ST. At 6 months, the stroma distribution reached values similar to those of control eyes and a dominant direction of the fibers re-appeared. The present results show that SHG microscopy imaging combined with the ST method is able to objectively monitor the temporal regeneration of the corneal organization after chemical burn. Future implementations of this approach into clinically adapted devices would help to diagnose and quantify corneal changes, not only due to chemical damages, but also as a result of disease or surgical procedures.
     
     
    Materias (normalizadas)
    Córnea - cirugía
    Materias Unesco
    2407 Biología Celular
    Palabras Clave
    Colágeno corneal
    Corneal collagen
    ISSN
    2156-7085
    Revisión por pares
    SI
    DOI
    10.1364/BOE.412819
    Patrocinador
    Ministerio de Sanidad. Instituto de Salud Carlos III (PI15/01906)
    Fundación Séneca (19897/GERM/15)
    Nota
    © 2021 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.
    Version del Editor
    https://www.osapublishing.org/boe/fulltext.cfm?uri=boe-12-2-756&id=446454#articleBody
    Propietario de los Derechos
    © 2021 Optical Society of America
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/45227
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP05 - Artículos de revista [198]
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    Dateien zu dieser Ressource
    Nombre:
    Assessment-corneal.collagen.pdf
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