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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/45358

    Título
    Clinical presentation of individuals with human T-Cell leukemia virus type-1 infection in spain
    Autor
    Mendoza, Carmen de
    Eiros Bouza, José MaríaAutoridad UVA Orcid
    Año del Documento
    2019
    Editorial
    Oxford University Press
    Descripción
    Producción Científica
    Documento Fuente
    De Mendoza, Carmen, [et al.].Clinical presentation of individuals with human T-Cell leukemia virus type-1 infection in spain, Open Forum Infectious Diseases, 2019, vol. 6, n.2
    Resumen
    Although only 8%–10% of persons infected with human T-cell leukemia virus type 1 (HTLV-1) may develop virus-associated diseases lifelong, misdiagnosis of asymptomatic infected carriers frequently leads to late diagnoses. Methods: A nationwide HTLV-1 register was created in Spain in 1989. A total of 351 infected persons had been reported by the end of 2017. We examined all new HTLV-1 diagnoses during the last decade and compared their clinical presentation. Results: A total of 247 individuals with HTLV-1 infection had been reported in Spain since year 2008. The incidence has remained stable with 20–25 new diagnoses yearly. Women represented 62%. Only 12% were native Spaniards, most of whom were foreigners from Latin America (72.5%). Up to 57 (23%) individuals presented clinically with HTLV-1-associated conditions, including subacute myelopathy (n = 24; 42.1%), T-cell lymphoma (n = 19; 33.3%), or Strongyloides stercoralis infestation (n = 8; 14%). Human T-cell leukemia virus type 1 diagnosis had been made either at blood banks (n = 109; 44%) or at clinics (n = 138; 56%). It is interesting to note that Spaniards and especially Africans were overrepresented among patients presenting with HTLV-1-associated illnesses, suggesting that misdiagnosis and late presentation are more frequent in these populations compared to Latin Americans. Conclusions: Given that 23% of new HTLV-1 diagnoses in Spain are symptomatic, underdiagnosis must be common. Although screening in blood banks mostly identifies asymptomatic Latin American carriers, a disproportionately high number of Spaniards and Africans are unveiled too late, that is, they already suffer from classic HTLV-1 illnesses.
    Materias Unesco
    32 Ciencias Médicas
    Palabras Clave
    Leucemia de células T adultas
    HTLV-1
    Epidemiología
    ISSN
    2328-8957
    Revisión por pares
    SI
    DOI
    10.1093/ofid/ofz036
    Version del Editor
    https://academic.oup.com/ofid/article/6/2/ofz036/5290444
    Propietario de los Derechos
    © Oxford University Press
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/45358
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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    • GIV - Artículos de Revista [46]
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    Attribution-NonCommercial-NoDerivatives 4.0 InternacionalLa licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 Internacional

    Universidad de Valladolid

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