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Título
Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients
Autor
Año del Documento
2018
Editorial
Springer Nature
Descripción
Producción Científica
Documento Fuente
Scientific Reports, 2018, vol. 8, 11999
Résumé
Early recognition of sepsis is a key factor to improve survival to this disease in surgical patients, since it
allows prompt control of the infectious source. Combining pro-infammatory and immunosupression
biomarkers could represent a good strategy to improve sepsis detection. Here we evaluated the
combination of procalcitonin (PCT) with gene expression levels of HLA-DRA to detect sepsis in a
cohort of 154 surgical patients (101 with sepsis and 53 with no infection). HLA-DRA expression was
quantifed using droplet digital PCR, a next-generation PCR technology. Area under the receiver
operating curve analysis (AUROC) showed that the PCT/HLA-DRA ratio outperformed PCT to detect
sepsis (AUROC [CI95%], p): PCT: 0.80 [0.73–0.88], <0.001; PCT/HLA-DRA: 0.85 [0.78–0.91], <0.001. In
the multivariate analysis, the ratio showed a superior ability to predict sepsis compared to that of PCT
(OR [CI 95%], p): PCT/HLA-DRA: 7.66 [1.82–32.29], 0.006; PCT: 4.21 [1.15–15.43] 0.030. Multivariate
analysis was confrmed using a new surgical cohort with 74 sepsis patients and 21 controls: PCT/HLADRA:
34.86 [1.22–995.08], 0.038; PCT: 5.52 [0.40–75.78], 0.201. In conclusion, the combination of PCT
with HLA-DRA is a promising strategy for improving sepsis detection in surgical patients.
Materias Unesco
3213 Cirugía
Palabras Clave
Procalcitonin
Procalcitonina
HLA-DR
Sepsis
ISSN
2045-2322
Revisión por pares
SI
Patrocinador
Instituto de Salud Carlos III - Consejeria de Sanidad de Castilla y Leon (grants EMER 07/050, PI15/01451 and PI16/01156)
Version del Editor
Propietario de los Derechos
© 2018 Springer Nature
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
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