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dc.contributor.authorGato Casado, Ángel Luis 
dc.contributor.authorMoro Balbás, José Antonio 
dc.contributor.authorAlonso Revuelta, María Isabel 
dc.contributor.authorBueno i Torrens, David
dc.contributor.authorMano Bonín, Anibal de la 
dc.date.accessioned2014-04-03T08:16:32Z
dc.date.available2014-04-03T08:16:32Z
dc.date.issued2005
dc.identifier.citationThe Anatomical record. Part A, 2005, p. 475-484es
dc.identifier.issn003-276Xes
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/4574
dc.descriptionProducción Científicaes
dc.description.abstractEarly in development, the behavior of neuroepithelial cells is controlled by several factors, which act in a developmentally regulated manner. Dif- fusible factors are secreted locally by the neuroepithelium itself, although other nearby structures may also be involved. Evidence suggests a physio- logical role for the cerebrospinal fluid in the development of the brain. Here, using organotypic cultures of chick embryo neuroepithelial explants from the mesencephalon, we show that the neuroepithelium in vitro is not able to self-induce cell survival, replication, and neurogenesis. We also show that the embryonic cerebrospinal fluid (E-CSF) promotes neuroepithelial stem cell survival and induces proliferation and neurogenesis in mesencephalic explants. These data strongly suggest that E-CSF is involved in the regu- lation of neuroepithelial cells behavior, supporting the hypothesis that this fluid plays a key role during the early development of the central nervous system.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherWiley-Lisses
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectEmbriologíaes
dc.subjectLíquido cefalorraquídeoes
dc.subjectNeurologíaes
dc.titleEmbryonic cerebrospinal fluid regulates neuroepithelial survival proliferation and neurogenesis in chick embryoses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1002/ar.a 20185es
dc.identifier.publicationfirstpage475es
dc.identifier.publicationissue284 Aes
dc.identifier.publicationlastpage484es
dc.identifier.publicationtitleThe anatomical recordes
dc.identifier.publicationvolume284 Aes
dc.peerreviewedSIes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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