dc.contributor.author | Salamanca Verdugo, Vanesa | |
dc.contributor.author | Albéniz Jiménez, Ana Carmen | |
dc.date.accessioned | 2021-04-08T17:32:46Z | |
dc.date.available | 2021-04-08T17:32:46Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Org. Chem. Front. DOI: 10.1039/D1QO00236H | es |
dc.identifier.uri | http://uvadoc.uva.es/handle/10324/46100 | |
dc.description | Producción Científica | es |
dc.description.abstract | The functionalization of simple arenes without coordinating directing groups is a challenge. Besides facing the task of cleaving the sluggish C-H bond, the process is hampered by the weak coordinating ability of the arene π-system to the metal, which results in reactions that need a large excess of the reactant arene. Using a well-defined palladium complex with the ligand [2, 2’-bipyridin]-6(1H)-one, we have found that the use of a moderately coordinating solvent allows a decrease of the amount of arene used. Moreover, for the least coordinating arenes, the co-solvent produces a significant accelerating effect by altering the concentration and relative stability of relevant metal species in the catalytic cycle as well as the catalyst resting state. t-Butyl methyl ketone (pinacolone) is one of the most effective co-solvents: Even if the ketone C-H bond cleaves easily, the final products are determined by the reductive elimination step (the product-forming step) so the target biaryl products are selectively observed. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.subject | Química | es |
dc.subject.classification | C-H activation | es |
dc.subject.classification | Catalysis | es |
dc.subject.classification | palladium | es |
dc.subject.classification | Arene functionalization | es |
dc.subject.classification | reaction mechanisms | es |
dc.title | Faster palladium-catalyzed arylation of simple arenes in the presence of a methylketone: beneficial effect of an a priori interfering solvent in C–H activation | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1039/D1QO00236H | es |
dc.relation.publisherversion | https://pubs.rsc.org/en/content/articlelanding/2021/qo/d1qo00236h#!divAbstract | es |
dc.identifier.publicationtitle | Organic Chemistry Frontiers | es |
dc.peerreviewed | SI | es |
dc.description.project | MINECO -AEI (grant CTQ2016-80913-P) | es |
dc.description.project | MICINN-AEI (grant PID2019-111406GB-I00) | es |
dc.description.project | Junta de Castilla y Leoń (grant VA224P20) | es |
dc.identifier.essn | 2052-4129 | es |
dc.type.hasVersion | info:eu-repo/semantics/submittedVersion | es |
dc.subject.unesco | 2306 Química Orgánica | es |
dc.subject.unesco | 2303 Química Inorgánica | es |