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dc.contributor.authorSalamanca Verdugo, Vanesa 
dc.contributor.authorAlbéniz Jiménez, Ana Carmen 
dc.date.accessioned2021-04-08T17:32:46Z
dc.date.available2021-04-08T17:32:46Z
dc.date.issued2021
dc.identifier.citationOrg. Chem. Front. DOI: 10.1039/D1QO00236Hes
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/46100
dc.descriptionProducción Científicaes
dc.description.abstractThe functionalization of simple arenes without coordinating directing groups is a challenge. Besides facing the task of cleaving the sluggish C-H bond, the process is hampered by the weak coordinating ability of the arene π-system to the metal, which results in reactions that need a large excess of the reactant arene. Using a well-defined palladium complex with the ligand [2, 2’-bipyridin]-6(1H)-one, we have found that the use of a moderately coordinating solvent allows a decrease of the amount of arene used. Moreover, for the least coordinating arenes, the co-solvent produces a significant accelerating effect by altering the concentration and relative stability of relevant metal species in the catalytic cycle as well as the catalyst resting state. t-Butyl methyl ketone (pinacolone) is one of the most effective co-solvents: Even if the ketone C-H bond cleaves easily, the final products are determined by the reductive elimination step (the product-forming step) so the target biaryl products are selectively observed.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.subjectQuímicaes
dc.subject.classificationC-H activationes
dc.subject.classificationCatalysises
dc.subject.classificationpalladiumes
dc.subject.classificationArene functionalizationes
dc.subject.classificationreaction mechanismses
dc.titleFaster palladium-catalyzed arylation of simple arenes in the presence of a methylketone: beneficial effect of an a priori interfering solvent in C–H activationes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1039/D1QO00236Hes
dc.relation.publisherversionhttps://pubs.rsc.org/en/content/articlelanding/2021/qo/d1qo00236h#!divAbstractes
dc.identifier.publicationtitleOrganic Chemistry Frontierses
dc.peerreviewedSIes
dc.description.projectMINECO -AEI (grant CTQ2016-80913-P)es
dc.description.projectMICINN-AEI (grant PID2019-111406GB-I00)es
dc.description.projectJunta de Castilla y Leoń (grant VA224P20)es
dc.identifier.essn2052-4129es
dc.type.hasVersioninfo:eu-repo/semantics/submittedVersiones
dc.subject.unesco2306 Química Orgánicaes
dc.subject.unesco2303 Química Inorgánicaes


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