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dc.contributor.authorYubero Benito, Sara
dc.contributor.authorRamudo, Laura
dc.contributor.authorManso, Manuel Antonio
dc.contributor.authorDios, Isabel de
dc.date.accessioned2021-06-21T11:54:57Z
dc.date.available2021-06-21T11:54:57Z
dc.date.issued2009
dc.identifier.citationBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009, vol. 1792, n. 12. p. 1205-1211es
dc.identifier.issn0925-4439es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/46968
dc.descriptionProducción Científicaes
dc.description.abstractThis study aimed to investigate the role of therapeutic dexamethasone (Dex) treatment on the mechanisms underlying chemokine expression during mild and severe acute pancreatitis (AP) experimentally induced in rats. Regardless of the AP severity, Dex (1 mg/kg), administered 1 h after AP, reduced the acinar cell activation of extracellular signal-regulated kinase (ERK) and c-Jun-NH2-terminal kinase (JNK) but failed to reduce p38-mitogen-activated protein kinase (MAPK) in severe AP. In both AP models, Dex inhibited the activation of nuclear factor-kappaB (NF-κB) and signal transducers and activators of transcription (STAT) factors. All of this resulted in pancreatic down-regulation of the chemokines monocyte chemoattractant protein-1 (MCP-1) and cytokine-induced neutrophil chemoattractant (CINC). Lower plasma chemokine levels as well as decreased amylasemia, hematocrit and plasma interleukin-1β (Il-1β) levels were found either in mild or severe AP treated with Dex. Pancreatic neutrophil infiltration was attenuated by Dex in mild but not in severe AP. In conclusion, by targeting MAPKs, NF-κB and STAT3 pathways, Dex treatment down-regulated the chemokine expression in different cell sources during mild and severe AP, resulting in decreased severity of the disease.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.classificationAcute pancreatitises
dc.subject.classificationPancreatitis agudaes
dc.subject.classificationChemokineses
dc.subject.classificationQuimiocinaes
dc.subject.classificationDexamethasonees
dc.subject.classificationDexametasonaes
dc.titleMechanisms of dexamethasone-mediated chemokine down-regulation in mild and severe acute pancreatitises
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2009 Elsevieres
dc.identifier.doi10.1016/j.bbadis.2009.10.001es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0925443909002257?via%3Dihubes
dc.peerreviewedSIes
dc.description.projectFondo Europeo de Desarrollo Regional - Fondo de Investigación Sanitaria (grant PI08/0035)es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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