dc.contributor.author | Coca Rojo, Armando | |
dc.contributor.author | Arias Cabrales, Carlos Enrique | |
dc.contributor.author | Valencia Peláez, Ana Lucia | |
dc.contributor.author | Burballa Tarrega, Carla Cristina | |
dc.contributor.author | Bustamante Munguira, Juan | |
dc.contributor.author | Redondo Pachón, María Dolores | |
dc.contributor.author | Acosta Ochoa, María Isabel | |
dc.contributor.author | Crespo Barrio, Marta | |
dc.contributor.author | Bustamante Bustamante, Jesús | |
dc.contributor.author | Mendiluce Herrero, Alicia | |
dc.contributor.author | Pascual Santos, Julio | |
dc.contributor.author | Pérez Saéz, María José | |
dc.date.accessioned | 2021-12-02T08:21:38Z | |
dc.date.available | 2021-12-02T08:21:38Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Scientific Reports, 2020, vol. 10, 17109 | es |
dc.identifier.issn | 2045-2322 | es |
dc.identifier.uri | https://uvadoc.uva.es/handle/10324/50759 | |
dc.description | Producción Científica | es |
dc.description.abstract | Pre-transplant prognostic scores help to optimize donor/recipient allocation and to minimize organ
discard rates. Since most of these scores come from the US, direct application in non-US populations is
not advisable. The Survival Benefit Estimator (SBE), built upon the Estimated Post-Transplant Survival
(EPTS) and the Kidney Donor Profile Index (KDPI), has not been externally validated. We aimed to
examine SBE in a cohort of Spanish kidney transplant recipients. We designed a retrospective cohortbased study of deceased-donor kidney transplants carried out in two different Spanish hospitals.
Unadjusted and adjusted Cox models were applied for patient survival. Predictive models were
compared using Harrell’s C statistics. SBE, EPTS and KDPI were independently associated with patient
survival (p ≤ 0.01 in all models). Model discrimination measured with Harrell’s C statistics ranged from
0.57 (KDPI) to 0.69 (SBE) and 0.71 (EPTS). After adjustment, SBE presented similar calibration and
discrimination power to that of EPTS. SBE tended to underestimate actual survival, mainly among
high EPTS recipients/high KDPI donors. SBE performed acceptably well at discriminating posttransplant
survival in a cohort of Spanish deceased-donor kidney transplant recipients, although its use as the main allocation guide, especially for high KDPI donors or high EPTS recipients requires further testing. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Springer | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Riñones - Enfermedades - Tratamiento | es |
dc.subject | Riñones - Trasplante | es |
dc.subject | Survival | |
dc.subject | Supervivencia | |
dc.title | Validation of a survival benefit estimator tool in a cohort of European kidney transplant recipients | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2020 Springer | es |
dc.identifier.doi | 10.1038/s41598-020-74295-3 | es |
dc.relation.publisherversion | https://www.nature.com/articles/s41598-020-74295-3 | es |
dc.identifier.publicationfirstpage | 1 | es |
dc.identifier.publicationissue | 1 | es |
dc.identifier.publicationlastpage | 10 | es |
dc.identifier.publicationtitle | Scientific Reports | es |
dc.identifier.publicationvolume | 10 | es |
dc.peerreviewed | SI | es |
dc.description.project | Rio Hortega contract (ISCIII-11453) | es |
dc.description.project | Fondo de Investigaciones Sanitarias - Fondo Europeo de Desarrollo Regional (project PI16/0617) | |
dc.description.project | Redinren (project RD16/0009/001) | |
dc.identifier.essn | 2045-2322 | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es |
dc.subject.unesco | 3205.06 Nefrología | es |