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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/50764

    Título
    Hypoglycemia following intravenous insulin plus glucose for hyperkalemia in patients with impaired renal function
    Autor
    Coca Rojo, Armando
    Valencia Peláez, Ana Lucía
    Bustamante Bustamante, Jesús
    Mendiluce Herrero, AliciaAutoridad UVA
    Floege, Jürgen
    Año del Documento
    2017
    Editorial
    Public Library of Science
    Descripción
    Producción Científica
    Documento Fuente
    PLoS ONE, 2017, vol. 12, n. 2
    Abstract
    Background: Hypoglycemia is a serious complication following the administration of insulin for hyperkalemia. We determined the incidence of hypoglycemia and severe hypoglycemia (blood glucose <70 or ≤40 mg/dl, respectively) in a cohort of AKI and non-dialysis dependent CKD patients who received an intravenous infusion of insulin plus glucose to treat hyperkalemia. Methods: We retrospectively reviewed charts of all AKI and non-dialysis dependent CKD patients who received 10 U of insulin plus 50 g glucose to treat hyperkalemia from December 1, 2013 to May 31, 2015 at our Department. Results: One hundred sixty four episodes of hyperkalemia were treated with insulin plus glucose and were eligible for analysis. Serum potassium levels dropped by 1.18 ± 1.01 mmol/l. Eleven treatments (6.1%) resulted in hypoglycemia and two (1.2%) in severe hypoglycemia. A lower pretreatment blood glucose tended to associate with a higher subsequent risk of hypoglycemia. Age, sex, renal function, an established diagnosis of diabetes or previous treatment were not associated with the development of this complication. We did not register any significant adverse events. Conclusion: Our intravenous regimen combining an infusion of insulin plus glucose effectively reduced serum potassium levels compared to previous studies and associated a low risk of symptomatic hypoglycemia and other complications.
    Materias (normalizadas)
    Hipoglucemia
    Insuficiencia renal
    Insulina
    Riñones - Enfermedades
    Materias Unesco
    3205.06 Nefrología
    ISSN
    1932-6203
    Revisión por pares
    SI
    DOI
    10.1371/journal.pone.0172961
    Version del Editor
    https://pubmed.ncbi.nlm.nih.gov/28245289/
    Propietario de los Derechos
    © 2017 Public Library of Science
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/50764
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Collections
    • DEP52 - Artículos de revista [55]
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