Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/50769
Título
Recipient age as a determinant factor of patient and graft survival
Año del Documento
2004
Editorial
Oxford University Press
European Renal Association
Descripción
Producción Científica
Documento Fuente
Nephrology Dialysis Transplantation, 2004, vol. 19, supl. 3, p. 16–20
Resumen
Background. Age of renal transplants has been related to death, alloimmune response and graft outcome. We reviewed the influence of patient age on transplant outcome in three cohorts of patients transplanted in Spain during the 1990s.
Methods. Patient age was categorized into four groups (I, 18–40; II, 41–50; III, 51–60; and IV, > 60 years). Risks factors for acute rejection were evaluated by logistic regression adjusting for transplant centre and transplantation year, while a Cox proportional hazard model was employed for analysing patient and graft survival.
Results. Older patients had a higher death rate (I, 3.5%; II, 7.7%; III, 13.2%; and IV, 16.9%; P<0.001), but a lower standardized mortality index (I, 7.6; II, 7.0; III, 5.8; and IV, 4.1; P = 0.0019). Older patients had the lowest risk of acute rejection [odds ratio (OR) 0.79 and 95% confidence interval (CI) 0.66–0.97 for group II; OR 0.75 and 95% CI 0.62–0.91 for group III; OR 0.43 and 95% CI 0.33–0.56 for group IV). Death-censored graft survival was poorer in patients older than 60 years (relative risk 1.40; 95% CI 1.09–1.80), but this result was not explained by any combination of patient age with donor age, delayed graft function or immunosuppression.
Conclusions. Patient age is a main determinant of transplant outcome. Although death rate is higher for older patients, standardized mortality was not. Thus, the efforts to reduce mortality should be also implemented in younger patients. Old patients have a low risk of acute rejection but a poorer death-censored graft survival. This last result was not explained by any controlled variable in our study.
Materias (normalizadas)
Riñones - Trasplante
Survival
Supervivencia
Materias Unesco
3205.06 Nefrología
ISSN
0931-0509
Revisión por pares
SI
Version del Editor
Propietario de los Derechos
© 2004 Oxford University Press
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
Aparece en las colecciones
Ficheros en el ítem
La licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 Internacional