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dc.contributor.authorLuis Román, Daniel Antonio de 
dc.contributor.authorAller de la Fuente, Rocío 
dc.contributor.authorIzaola Jauregui, Olatz
dc.contributor.authorPrimo Martín, David
dc.date.accessioned2022-01-10T12:39:57Z
dc.date.available2022-01-10T12:39:57Z
dc.date.issued2021
dc.identifier.citationJournal of Human Nutrition and Dietetics, 2021, p. 1-9es
dc.identifier.issn0952-3871es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/51185
dc.descriptionProducción Científicaes
dc.description.abstractBackground:The single nucleotide polymorphism (SNP) (rs10401670) of theRETNgene has been associated with metabolic disorder in obese subjects andhas scarcely been evaluated after dietary interventions. The present studyaimed to analyse the effects of thers10401670 RETNgene polymorphismon metabolic changes secondary to weight loss and secondary to a high‐fathypocaloric diet with a Mediterranean dietary pattern.Methods:A Caucasian population comprising 284 obese patients withoutdiabetes mellitus was analysed. Before and after 3 months of a high‐fathypocaloric diet with a Mediterranean pattern, an anthropometric evaluation,an assessment of nutritional intake and a biochemical analysis were per-formed. A statistical analysis was conducted for the combinedCTandTTas agroup and for wild‐typeCCas a second group.Results:Decreases in weight, body mass index (BMI), fat mass, systolic bloodpressure and waist circumference were similar in both genotypes groups. InTallele carriers, insulin, homeostatic model assessment for insulin resistance(HOMA‐IR), triglycerides and C‐reactive protein levels were decreased.The decrease in these parameters was statistically significant for triglycerides(−22.3 ± 9.3 mg dl–1:p= 0.03), C‐reactive protein (−2.8 ± 0.5 mg dl–1:p= 0.03), insulin (−7.4 ± 2.9 mUI L–1:p= 0.03) and HOMA‐IR (−2.4 ± 1.0:p= 0.02). Leptin levels were decreased in both genotypes groups after thehypocaloric diet, as well as the anthropometric parameters BMI, weight, waistcircumference and fat mass. Resistin and adiponectin levels remained un-changed in both groups.Conclusions:In the present study, we have detected a significant associationbetween theTallele of this SNP and a better response of insulin resistance,triglycerides and C‐reactive protein compared to nonTallele carriers afterweight loss with a high‐fat hypocaloric diet and a Mediterranean diet.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherWileyes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.classificationHigh‐fat hypocaloric dietes
dc.subject.classificationInsulin resistancees
dc.subject.classificationResistines
dc.subject.classificationrs10401670 gene variantes
dc.titleRole of the rs10401670 variant in the resistin gene on the metabolic response after weight loss secondary to a high‐fat hypocaloric diet with a Mediterranean patternes
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2021 The Authorses
dc.identifier.doi10.1111/jhn.12975es
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1111/jhn.12975es
dc.identifier.publicationtitleJournal of Human Nutrition and Dieteticses
dc.peerreviewedSIes
dc.identifier.essn1365-277Xes
dc.rightsAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones
dc.subject.unesco32 Ciencias Médicases


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