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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/53423

    Título
    Diurnal variation on tear stability and correlation with tear cytokine concentration
    Autor
    Arroyo del Arroyo, CristinaAutoridad UVA
    Byambajav, Mungunshur
    Fernández Martínez, ItziarAutoridad UVA Orcid
    Martin, Eilidh
    González García, María JesúsAutoridad UVA Orcid
    López Miguel, AlbertoAutoridad UVA Orcid
    Valencia Nieto, LauraAutoridad UVA Orcid
    Hagan, Suzanne
    Enriquez De Salamanca Aladro, AmaliaAutoridad UVA Orcid
    Año del Documento
    2022
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    Contact Lens and Anterior Eye, 2022, vol. 45, n. 6, 101705
    Abstract
    Purpose: To investigate the effect of time of day on tear evaporation rate (TER) and tear break-up time, and its possible relationship with the concentration of inflammatory tear molecules (cytokines) in healthy subjects. Methods: Participants with healthy ocular surfaces attended 3 visits, including the screening visit (V0), the 2nd visit (V1) and the 3rd visit (V2). There were 7-day intervals between visits. Participants with Dry Eye Disease (DED) were excluded by using appropriate clinical tests during V0. Clinical evaluation (TER and Non-Invasive Tear Break-Up Time (NITBUT)) and tear collection were performed during V1 and V2, between 9 and 10AM and 3-4PM. The relative humidity and temperature of the examination room were also measured. The tear fluid concentrations of 15 cytokines were measured by multiplex bead analysis. Results: Seven men and 10 women (mean age ± S.D; 25.1 ± 6.63 years old) participated in the study. There were no differences in neither the TER and NITBUT outcomes, nor humidity and temperature among times or visits. Eleven out of the 15 cytokines measured were detectable in tear fluids in > 50% of the participants. In the tear levels, no significant (p > 0.05) inter- and/or intra-day differences were detected for EGF, fractalkine, IL-1RA, IL-1β and IP-10. However, significant inter-day differences were found in the tear levels of IL-10 (p = 0.027), IFN-γ (p = 0.035) and TNF-α(p = 0.04) and intra-day differences in the tear levels of IL-8/CXCL8 (p = 0.034) and MCP-1 (p = 0.002). A significant correlation between TER and IL1-β, IL-2, and Fractalkine (p = 0.03, p = 0.03 and p = 0.046, respectively) was found at V1. Conclusions: NITBUT and TER values had no significant variability over the course of a day (AM versus PM), or on different days in healthy participants when humidity and temperature were constant. However, some tear molecule levels did show inter- and intra-day variability, having an inconsistent and moderate correlation with TER diurnal variation.
    Materias Unesco
    3201.09 Oftalmología
    Palabras Clave
    Cytokines
    Citoquinas
    ISSN
    1367-0484
    Revisión por pares
    SI
    DOI
    10.1016/j.clae.2022.101705
    Version del Editor
    https://www.sciencedirect.com/science/article/pii/S1367048422001436?via%3Dihub
    Propietario de los Derechos
    © 2022 The Authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/53423
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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