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Título
Amitriptyline for post-COVID headache: effectiveness, tolerability, and response predictors
Autor
Año del Documento
2022
Editorial
Springer
Descripción
Producción Científica
Documento Fuente
Journal of Neurology, 2022.
Résumé
Background Headache is one of the most frequently reported symptoms in post-COVID patients. The clinical phenotype of
COVID-19 headache combines phenotypic features of both tension-type headache (TTH) and migraine. We aimed to assess
the efectiveness, side efects and predictors of amitriptyline (AMT) response in a real-world study setting.
Methods We performed an observational multicentric study with a retrospective cohort. All consecutive patients with con frmed COVID-19 infection who received AMT for post-COVID headache from March 2020 to May 2021 were included.
Response was evaluated by the reduction in the number of headache days per month (HDM) between weeks 8 and 12,
compared with the baseline. We explored which variables were associated with a higher probability of response to AMT.
Results Forty-eight patients were eligible for the study, 40/48 (83.3%) females, aged 46.85 (SD: 13.59) years. Patients had
history of migraine 15/48 (31.3%) or TTH 5/48 (10.4%). The mean reduction of HDM was 9.6 (SD: 10.9; 95% CI 6.5, 12.7)
days. Only 2/48 (5%) of patients discontinued AMT due to poor tolerability. History of TTH (10.9, 95% CI 1.3, 20.6) and
nausea (−8.5, 95% CI −14.6, −2.5) were associated with AMT response.
Conclusions This study provides real-world evidence of the potential beneft of AMT in patients with post-COVID-19
headache, especially in patients with history of TTH and without concomitant nausea.
Materias Unesco
32 Ciencias Médicas
Palabras Clave
Migraine
Amitriptyline
COVID-19
Tension-type headache
Long-haulers
ISSN
0340-5354
Revisión por pares
SI
Patrocinador
Ministerio de Economía y Competitividad (Instituto de Salud Carlos III) & Unión Europea (Fondo Social Europeo, FSE+) a través del Río Hortega Beca (CM21/00178)
Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCLE
Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCLE
Version del Editor
Propietario de los Derechos
© 2022 The Authors
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
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