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dc.contributor.authorPinilla Martín, Cintya
dc.contributor.authorSalamanca Verdugo, Vanesa 
dc.contributor.authorLledós, Agustí
dc.contributor.authorAlbéniz Jiménez, Ana Carmen 
dc.date.accessioned2022-11-14T14:22:31Z
dc.date.available2022-11-14T14:22:31Z
dc.date.issued2022
dc.identifier.citationACS Catalysis, 2022, vol. 12. p. 14527–14532es
dc.identifier.issn2155-5435es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/57051
dc.descriptionProducción Científicaes
dc.description.abstractMetal-catalyzed C–H functionalizations on the aryl ring of anilines usually need cumbersome N-protection–deprotection strategies to ensure chemoselectivity. We describe here the Pd-catalyzed direct C–H arylation of unprotected anilines with no competition of the N-arylation product. The ligand [2,2′-bipyridin]-6(1H)-one drives the chemoselectivity by kinetic differentiation in the product-forming step, while playing a cooperating role in the C–H cleavage step. The latter is favored in an anionic intermediate where the NH moiety is deprotonated, driving the regioselectivity of the reaction toward ortho substitution.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherAmerican Chemical Societyes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.classificationPalladiumes
dc.subject.classificationPaladioes
dc.subject.classificationAnilineses
dc.subject.classificationAnilinases
dc.subject.classificationArylationes
dc.subject.classificationArilaciónes
dc.subject.classificationPyridoneses
dc.subject.classificationPiridonases
dc.titlePalladium-catalyzed ortho C–H arylation of unprotected anilines: Chemo- and regioselectivity enabled by the cooperating ligand [2,2′-bipyridin]-6(1H)-onees
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2022 American Chemical Societyes
dc.identifier.doi10.1021/acscatal.2c05206es
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acscatal.2c05206es
dc.peerreviewedSIes
dc.description.projectMinisterio de Ciencia, Innovación y Universidades (projects PID2019-111406GB-I00 and PID-2020-116861GB-I00)es
dc.description.projectJunta de Castilla y Leon - Fondo Europeo de Desarrollo Regional (projects VA224P20 and VA087-18)es
dc.rightsAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones
dc.subject.unesco2303 Química Inorgánicaes


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