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dc.contributor.authorParada, Carolina
dc.contributor.authorGato Casado, Ángel Luis 
dc.contributor.authorBueno i Torrens, David
dc.date.accessioned2014-09-03T08:46:02Z
dc.date.available2014-09-03T08:46:02Z
dc.date.issued2008
dc.identifier.citationDevelopmental Neuroscience, June 2008, vol. 19, n. 9. p. 945-950es
dc.identifier.issn0378-5866es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/5797
dc.descriptionProducción Científicaes
dc.description.abstractEmbryonic cerebrospinal £uid (E-CSF) is involved in the regulation of survival, proliferation and neurogenesis of neuroectodermal progenitor cells, aswell as in the control ofmesencephalic gene expression in collaboration with the isthmic organizer. Recently, we showed the presence of retinol-binding protein (RBP) within the E-CSF proteome.RBP is an all-trans retinol carrier, amolecule that can be metabolized into retinoic acid, a morphogen involved in central nervous system (CNS) morphogenesis and patterning. Here we demonstrate the presence of all-trans retinol within the E-CSF and analyse the dynamics of RBP and all-trans retinolwithin this £uid, as well as the expression of retinoic acid-synthesizing enzymes during early CNS development. Our results suggest a relationship between the dynamics of these molecules and the early events of CNS patterning.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherLippincott Williams and Wilkinses
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectFluidos orgánicoses
dc.subjectRetinoles
dc.subjectEmbriología humanaes
dc.subjectCerebro - Desarrolloes
dc.titleAll-trans retinol and retinol-binding protein from embryonic cerebrospinal £uid exhibit dynamic behaviour during early central nervous system developmentes
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holderLippincott Williams and Wilkinses
dc.identifier.publicationfirstpage945es
dc.identifier.publicationissue9es
dc.identifier.publicationlastpage950es
dc.identifier.publicationtitleDevelopmental Neurosciencees
dc.identifier.publicationvolume19es
dc.peerreviewedSIes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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