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    • SCIENTIFIC PRODUCTION
    • Departamentos
    • Dpto. Anatomia y Radiología
    • DEP04 - Artículos de revista
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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/5802

    Título
    Why the embryo still matters: CSF and the neuroepithelium as interdependent
    Autor
    Gato Casado, Ángel LuisAutoridad UVA Orcid
    Desmond, Mary E.
    Año del Documento
    2009
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    Developmental Biology, 2009, p. 1-10
    Abstract
    The key focus of this review is that both the neuroepithelium and embryonic cerebrospinal fluid (CSF) work in an integrated way to promote embryonic brain growth, morphogenesis and histiogenesis. The CSF generates pressure and also contains many biologically powerful trophic factors; both play key roles in early brain development. Accumulation of fluid via an osmotic gradient creates pressure that promotes rapid expansion of the early brain in a developmental regulated way, since the rates of growth differ between the vesicles and for different species. The neuroepithelium and ventricles both contribute to this growth but by different and coordinated mechanisms. The neuroepithelium grows primarily by cell proliferation and at the same time the ventricle expands via hydrostatic pressure generated by active transport of Na+ and transport or secretion of proteins and proteoglycans that create an osmotic gradient which contribute to the accumulation of fluid inside the sealed brain cavity. Recent evidence shows that the CSF regulates relevant aspects of neuroepithelial behavior such as cell survival, replication and neurogenesis by means of growth factors and morphogens. Here we try to highlight that early brain development requires the coordinated interplay of the CSF contained in the brain cavity with the surrounding neuroepithelium. The information presented is essential in order to understand the earliest phases of brain development and also how neuronal precursor behavior is regulated.
    Materias (normalizadas)
    Cerebro
    Embriologia humana
    Fluidos orgánicos
    ISSN
    0012-1606
    Revisión por pares
    SI
    DOI
    10.106/j.ydbio.2008.12.029
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/5802
    Derechos
    openAccess
    Collections
    • DEP04 - Artículos de revista [31]
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalExcept where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International

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