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dc.contributor.authorCampillo Sánchez, Francisco
dc.contributor.authorUsategui Martín, Ricardo 
dc.contributor.authorRuiz de Temiño de la Peña, Ángela 
dc.contributor.authorGil, Judith
dc.contributor.authorRuiz Mambrilla, Marta María 
dc.contributor.authorFernández Gómez, José María Fidel 
dc.contributor.authorDueñas Laita, Antonio 
dc.contributor.authorPérez Castrillon, José Luis 
dc.date.accessioned2023-03-17T09:55:11Z
dc.date.available2023-03-17T09:55:11Z
dc.date.issued2020
dc.identifier.citationJournal Clinical Medicine, 2020, vol.9, n.6, 1732es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/58971
dc.descriptionProducción Científicaes
dc.description.abstractBackground: Insulin may play a key role in bone metabolism, where the anabolic effect predominates. This study aims to analyze the relationship between insulin resistance and bone quality using the trabecular bone score (TBS) and three-dimensional dual-energy X-ray absorptiometry (3D-DXA) in non-diabetic postmenopausal women by determining cortical and trabecular compartments. Methods: A cross-sectional study was conducted in non-diabetic postmenopausal women with suspected or diagnosed osteoporosis. The inclusion criteria were no menstruation for more than 12 months and low bone mass or osteoporosis as defined by DXA. Glucose was calculated using a Hitachi 917 auto-analyzer. Insulin was determined using an enzyme-linked immunosorbent assay (EIA). Insulin resistance was estimated using a homeostasis model assessment of insulin resistance (HOMA-IR). DXA, 3D-DXA, and TBS were thus collected. Moreover, we examined bone parameters according to quartile of insulin, hemoglobin A1C (HbA1c), and HOMA-IR. Results: In this study, we included 381 postmenopausal women. Women located in quartile 4 (Q4) of HOMA-IR had higher values of volumetric bone mineral density (vBMD) but not TBS. The increase was higher in the trabecular compartment (16.4%) than in the cortical compartment (6.4%). Similar results were obtained for insulin. Analysis of the quartiles by HbA1c showed no differences in densitometry values, however women in Q4 had lower levels of TBS. After adjusting for BMI, statistical significance was maintained for TBS, insulin, HOMA-IR, and HbA1c. Conclusions: In non-diabetic postmenopausal women there was a direct relationship between insulin resistance and vBMD, whose effect is directly related to greater weight. TBS had an inverse relationship with HbA1c, insulin, and insulin resistance unrelated to weight. This might be explained by the formation of advanced glycosylation products (AGEs) in the bone matrix, which reduces bone deformation capacity and resistance, as well as increases fragility.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectGynecologyes
dc.subjectEndocrinologyes
dc.subjectOsteoporosises
dc.subject.classificationHOMA-IRes
dc.subject.classificationHbA1ces
dc.subject.classificationvBMDes
dc.subject.classificationTBSes
dc.subject.classification3D-DXAes
dc.titleRelationship between insulin resistance (HOMA-IR), trabecular bone score (TBS), and three-dimensional dual-energy X-ray absorptiometry (3D-DXA) in non-diabetic postmenopausal womenes
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2020 The Authorses
dc.identifier.doi10.3390/jcm9061732es
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/9/6/1732es
dc.identifier.publicationfirstpage1732es
dc.identifier.publicationissue6es
dc.identifier.publicationtitleJournal of Clinical Medicinees
dc.identifier.publicationvolume9es
dc.peerreviewedSIes
dc.identifier.essn2077-0383es
dc.rightsAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones
dc.subject.unesco32 Ciencias Médicases


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