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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/59014

    Título
    Iron and physical activity: Bioavailability enhancers, properties of black pepper (Bioperine®) and potential applications
    Autor
    Fernández Lázaro, DiegoAutoridad UVA
    Mielgo Ayuso, Juan FranciscoAutoridad UVA Orcid
    Córdova Martínez, AlfredoAutoridad UVA Orcid
    Seco Calvo, Jesús
    Año del Documento
    2020
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Nutrients, 2020, vol.12, n. 6, 1886
    Abstract
    Black pepper (Piper nigrum L.) has been employed in medicine (epilepsy, headaches, and diabetes), where its effects are mainly attributed to a nitrogen alkaloid called piperidine (1-(1-[1,3-benzodioxol-5-yl]-1-oxo-2,4 pentenyl) piperidine). Piperine co-administered with vitamins and minerals has improved its absorption. Therefore, this study aimed to describe the impact of the joint administration of iron (Fe) plus black pepper in physically active healthy individuals. Fe is a micronutrient that aids athletic performance by influencing the physiological functions involved in endurance sports by improving the transport, storage, and utilization of oxygen. Consequently, athletes have risk factors for Fe depletion, Fe deficiency, and eventually, anemia, mainly from mechanical hemolysis, gastrointestinal disturbances, and loss of Fe through excessive sweating. Declines in Fe stores have been reported to negatively alter physical capacities such as aerobic capacity, strength, and skeletal muscle recovery in elite athletes. Thus, there is a need to maintain Fe storage, even if Fe intake meets the recommended daily allowance (RDA), and Fe supplementation may be justified in physically active individuals, in states of Fe deficiency, with or without anemia. Females, in particular, should monitor their Fe hematological profile. The recommended oral Fe supplements are ferrous or ferric salts, sulfate, fumarate, and gluconate. These preparations constitute the first line of treatment; however, the high doses administered have gastrointestinal side effects that reduce tolerance and adherence to treatment. Thus, a strategy to counteract these adverse effects is to improve the bioavailability of Fe. Therefore, piperine may benefit the absorption of Fe through its bioavailability enhancement properties. Three research studies of Fe associated with black pepper have reported improvements in parameters related to the metabolism of Fe, without adverse effects. Although more research is needed, this could represent an advance in oral Fe supplementation for physically active individuals.
    Materias (normalizadas)
    Fisiología
    Medicina deportiva
    Farmacología
    Materias Unesco
    3209 Farmacología
    2411 Fisiología Humana
    Palabras Clave
    Piperine
    Iron
    Supplementation
    Physical activity
    Piperina
    Hierro
    Suplementación
    Actividad física
    Revisión por pares
    SI
    DOI
    10.3390/nu12061886
    Version del Editor
    https://www.mdpi.com/2072-6643/12/6/1886
    Propietario de los Derechos
    © 2020 The Authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/59014
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP06 - Artículos de revista [352]
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    Universidad de Valladolid

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