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dc.contributor.author | Vay, Laura | |
dc.contributor.author | Hernández San Miguel, Esther | |
dc.contributor.author | Santo Domingo, Jaime | |
dc.contributor.author | Domínguez Lobatón, María Carmen | |
dc.contributor.author | Moreno Díaz-Calderón, Alfredo | |
dc.contributor.author | Montero Zoccola, María Teresa | |
dc.contributor.author | Álvarez Martín, Javier | |
dc.date.accessioned | 2014-09-16T10:59:24Z | |
dc.date.available | 2014-09-16T10:59:24Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Journal of Physiology, 2007, vol. 580, n. 1, p. 39-49 | es |
dc.identifier.issn | 0022-3751 | es |
dc.identifier.uri | http://uvadoc.uva.es/handle/10324/5984 | |
dc.description | Producción Científica | es |
dc.description.abstract | The recent availability of activators of the mitochondrial Ca2+ uniporter allows direct testing of the influence of mitochondrial Ca2+ uptake on the overall Ca2+ homeostasis of the cell. We show here that activation of mitochondrial Ca2+ uptake by 4,4 ,4 -(4- propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol (PPT) or kaempferol stimulates histamine-induced Ca2+ release from the endoplasmic reticulum (ER) and that this effect is enhanced if the mitochondrial Na+–Ca2+ exchanger is simultaneously inhibited with CGP37157. This suggests that both Ca2+ uptake and release from mitochondria control the ability of local Ca2+ microdomains to produce feedback inhibition of inositol 1,4,5-trisphosphate receptors (InsP3Rs). In addition, the abilityof mitochondria tocontrolCa2+ release fromtheERallowsthemtomodulate cytosolic Ca2+ oscillations. In histamine stimulatedHeLa cells and human fibroblasts, both PPT and kaempferol initially stimulated and later inhibited oscillations, although kaempferol usually induced a more prolonged period of stimulation. Both compounds were also able to induce the generation of Ca2+ oscillations in previously silent fibroblasts. Our data suggest that cytosolic Ca2+ oscillations are exquisitely sensitive to the rates of mitochondrial Ca2+ uptake and release, which precisely control the size of the local Ca2+ microdomains around InsP3Rs and thus the ability to produce feedback activation or inhibition of Ca2+ release. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Wiley | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Calcio en el organismo | es |
dc.title | Modulation of Ca2+ release and Ca2+ oscillations in HeLa cells and fibroblasts by mitochondrial Ca2+ uniporter stimulation | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1113/jphysiol.2006.126391 | es |
dc.identifier.publicationfirstpage | 39 | es |
dc.identifier.publicationissue | 1 | es |
dc.identifier.publicationlastpage | 49 | es |
dc.identifier.publicationtitle | Journal of Physiology | es |
dc.identifier.publicationvolume | 580 | es |
dc.peerreviewed | SI | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
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