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dc.contributor.authorPedrosa Naudín, M. Aránzazu
dc.contributor.authorGutiérrez Abejón, Eduardo
dc.contributor.authorHerrera Gómez, Francisco Magno
dc.contributor.authorFernández Lázaro, Diego 
dc.contributor.authorÁlvarez González, Francisco Javier 
dc.date.accessioned2023-07-14T11:33:45Z
dc.date.available2023-07-14T11:33:45Z
dc.date.issued2022
dc.identifier.citationPharmaceutics, 2022, Vol. 14, Nº. 12, 2696es
dc.identifier.issn1999-4923es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/60298
dc.descriptionProducción Científicaes
dc.description.abstractAntidepressants are a commonly prescribed psychotropic medication, and their use has increased in recent years. Medication non-adherence in patients with mental disorders is associated with worse health outcomes. A population-based registry study to assess antidepressant non-adherence during 2021 has been carried out. An indirect method based on the medication possession ratio (MPR) has been utilized. Patients with a MPR under 80% were classified as non-adherent. A multivariate logistic regression to identify non-adherence predictors has been used, considering sociodemographic (age, sex, institutionalization and urbanicity) and health related variables (diagnostics, antidepressant class, multiple prescribers, and polypharmacy). In 2021, 10.6% of the Castile and Leon population used antidepressants. These patients were institutionalized (7.29%), living in urban areas (63.44%), polymedicated with multiple prescribers (57.07%), and using serotonin selective reuptake inhibitors (SSRIs) (54.77%), other antidepressants (46.82%) or tricyclic antidepressants (TCAs) (13.76%). Antidepressants were prescribed mainly for depression (36.73%) and anxiety (29.24%). Non-adherence to antidepressants was more frequent in men (20.56%) than in woman (19.59%) and decreased with increasing age (32% up to 17 years old vs. 13.76% over 80 years old). TCAs were associated with the highest prevalence of non-adherence (23.99%), followed by SSRIs (20.19%) and other antidepressants (18.5%). Predictors of non-adherence in patients on antidepressants were: living in urban areas, using TCAs, and pain occurrence. Non-adherence to antidepressants decreases with aging. Being female, institutionalization, being polymedicated and having depression/anxiety alongside another psychiatric diagnosis are protective factors against non-adherence. The MPR is a robust indicator for the clinician to identify non-adherent patients for monitoring, and adopt any necessary corrective actions.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAntidepressantses
dc.subjectAntidepresivoses
dc.subjectDrug utilizationes
dc.subjectMedicamentos - Usoes
dc.subjectPsychiatryes
dc.subjectPharmacyes
dc.subjectPsychopharmacologyes
dc.subjectDepressiones
dc.subjectDepresión mentales
dc.subjectAnxietyes
dc.subjectAnsiedades
dc.subjectPsychopathologyes
dc.subjectPsychotropic drugses
dc.subjectDrogas psicotrópicases
dc.titleNon-adherence to antidepressant treatment and related factors in a region of Spain: A population-based registry studyes
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2022 The Authorses
dc.identifier.doi10.3390/pharmaceutics14122696es
dc.relation.publisherversionhttps://www.mdpi.com/1999-4923/14/12/2696es
dc.identifier.publicationfirstpage2696es
dc.identifier.publicationissue12es
dc.identifier.publicationtitlePharmaceuticses
dc.identifier.publicationvolume14es
dc.peerreviewedSIes
dc.description.projectInstituto de Salud Carlos III y Fondo Europeo de Desarrollo Regional (FEDER) - (grant RD16/0017/0006)es
dc.identifier.essn1999-4923es
dc.rightsAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones
dc.subject.unesco3209 Farmacologíaes
dc.subject.unesco3211 Psiquiatríaes
dc.subject.unesco3209.09 Psicofarmacologíaes


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