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dc.contributor.author | Varga Martínez, Olga de la | |
dc.contributor.author | Martín Fernández, Marta | |
dc.contributor.author | Heredia Rodríguez, María | |
dc.contributor.author | Ceballos Laita, Luis | |
dc.contributor.author | Cubero Gallego, Héctor | |
dc.contributor.author | Priede Vimbela, Juan Manuel | |
dc.contributor.author | Bardají Carrillo, Miguel | |
dc.contributor.author | Sánchez de Prada, Laura | |
dc.contributor.author | López Herrero, Rocio | |
dc.contributor.author | Jorge Monjas, Pablo | |
dc.contributor.author | Tamayo Gómez, Eduardo | |
dc.contributor.author | Gómez Sánchez, Esther | |
dc.date.accessioned | 2023-07-19T11:14:15Z | |
dc.date.available | 2023-07-19T11:14:15Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Journal of Clinical Medicine, 2022, Vol. 11, Nº. 24, 7274 | es |
dc.identifier.issn | 2077-0383 | es |
dc.identifier.uri | https://uvadoc.uva.es/handle/10324/60425 | |
dc.description | Producción Científica | es |
dc.description.abstract | Background: procalcitonin is a valuable marker in the diagnosis of bacterial infections; however, the impairment of renal function can influence its diagnostic precision. The objective of this study is to evaluate the differential behaviour of procalcitonin, as well as its usefulness in the diagnosis of postoperative pulmonary infection after cardiac surgery, depending on the presence or absence of impaired renal function. Materials and methods: A total of 805 adult patients undergoing cardiac surgery with extracorporeal circulation (CBP) were prospectively recruited, comparing the behaviour of biomarkers between the groups with and without postoperative pneumonia and according to the presence or absence of renal dysfunction. Results: Pulmonary infection was diagnosed in 42 patients (5.21%). In total, 228 patients (28.32%) presented postoperative renal dysfunction. Procalcitonin was significantly higher in infected patients, even in the presence of renal dysfunction. The optimal procalcitonin threshold differed markedly in patients with renal dysfunction compared to patients without renal dysfunction (1 vs. 0.78 ng/mL p < 0.05). The diagnostic accuracy of procalcitonin increased significantly when the procalcitonin threshold was adapted to renal function. Conclusions: Procalcitonin is an accurate marker of postoperative infection in cardiac surgery, even in the presence of renal dysfunction. Renal function is an important determinant of procalcitonin levels and, therefore, its diagnostic thresholds must be adapted in the presence of renal dysfunction. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Heart - Surgery - Patients - Medical care | es |
dc.subject | Cardiac surgery | es |
dc.subject | Cardiology | es |
dc.subject | Cardiovascular, aparato - Cirugía | es |
dc.subject | Corazón - Cirugía | es |
dc.subject | Kidneys - Diseases | es |
dc.subject | Riñones - Enfermedades | es |
dc.subject | Nephrology | es |
dc.subject | Biochemical markers | es |
dc.subject | Nosocomial infections | es |
dc.subject | Infecciones de hospital | es |
dc.subject.classification | Procalcitonin | es |
dc.subject.classification | Procalcitonina | es |
dc.title | Influence of renal dysfunction on the differential behaviour of procalcitonin for the diagnosis of postoperative infection in cardiac surgery | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2022 The Authors | es |
dc.identifier.doi | 10.3390/jcm11247274 | es |
dc.relation.publisherversion | https://www.mdpi.com/2077-0383/11/24/7274 | es |
dc.identifier.publicationfirstpage | 7274 | es |
dc.identifier.publicationissue | 24 | es |
dc.identifier.publicationtitle | Journal of Clinical Medicine | es |
dc.identifier.publicationvolume | 11 | es |
dc.peerreviewed | SI | es |
dc.description.project | Instituto de Salud Carlos III - (grant COV20/00491, PI18/01238, CIBERINFEC CB21/13/00051) | es |
dc.description.project | Junta de Castilla y León - (grant VA321P18, GRS 1922/A/19, GRS 2057/A/19) | es |
dc.description.project | Junta de Castilla y León, Consejería de Educación - (grant VA256P20) | es |
dc.description.project | Fundación Ramón Areces - (grant CIVP19A5953) | es |
dc.description.project | Instituto de Salud Carlos III y Fondo Europeo de Desarrollo Regional (FEDER)/Fondo Social Europeo - (grant CM20/00138) | es |
dc.identifier.essn | 2077-0383 | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es |
dc.subject.unesco | 3205.01 Cardiología | es |
dc.subject.unesco | 3205.06 Nefrología | es |
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