Role of Beta2 adrenergic receptor polymorphism (rs1042714) on body weight and glucose metabolism response to a meal-replacement hypocaloric diet

Abstract

The Beta2-adrenergic receptor (ADRB2) is involved in energy balance regulation. The objective of our study was to evaluate the role of rs1042714 genetic variant of ADRB2 gene on weight loss, body composition and metabolic changes secondary to partial Meal replacement (pMR) hypocaloric diet in women with obesity. G allele of rs rs1042714 predicts the magnitude of weight loss resulting from a pMR diet. These adiposity improvements produce a better improvement of insulin resistance and percentage of impaired glucose metabolism in G allele carriers.