dc.contributor.author | Ganfornina Álvarez, María Dolores | |
dc.contributor.author | Sánchez Romero, Diego | |
dc.contributor.author | Pagano, Aldo | |
dc.contributor.author | Tonachini, Laura | |
dc.contributor.author | Descalzi-Cancedda, Fiorella | |
dc.contributor.author | Martínez, Salvador | |
dc.date.accessioned | 2014-09-19T10:30:48Z | |
dc.date.available | 2014-09-19T10:30:48Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Developmental Dynamics, 2005, vol. 232, p. 191-199 | es |
dc.identifier.issn | 1058-8388 | es |
dc.identifier.uri | http://uvadoc.uva.es/handle/10324/6078 | |
dc.description | Producción Científica | es |
dc.description.abstract | The insect Lazarillo and the mammalian apolipoprotein D (ApoD) are orthologous members of the lipocalin
protein family. We report the cloning and embryonic expression of chicken ApoD, the first molecularly
characterized nonmammalian ApoD. We also report the ApoD expression in mouse during postnatal
development and some novel aspects of the expression of the paralogous lipocalin prostaglandin D-synthase
(PGDS) and discuss these results in view of the lipocalin family evolution in vertebrates. ApoD is expressed
in subsets of central nervous system (CNS) neurons and glia during late chicken embryogenesis. Contrary
to mouse ApoD, no expression appears in neural crest-derived cephalic mesenchyme and blood vessel
pericytes. Also, ApoD is expressed in developing chicken feathers. These expressions are corroborated by
quantitative reverse transcriptase-polymerase chain reaction profiles. ApoD is expressed during mouse
postnatal development in a subset of CNS neurons, astrocytes and oligodendrocytes, but also in meninges
and pericytes. Chicken PGDS is expressed in brain meninges and perivascular cells. Our results suggest
that the amniote last common ancestor expressed ApoD and PGDS in the brain during embryogenesis. ApoD
appears restricted to ectodermal derivatives, whereas PGDS is expressed by derivatives of the three germ
layers. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Wiley-Liss | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Nervioso, Sistema - Evolución | es |
dc.subject | Embriología | |
dc.subject | Células clonales | |
dc.title | Molecular Characterization and Developmental Expression Pattern of the Chicken Apolipoprotein D Gene: Implications for the Evolution of Vertebrate Lipocalins | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1002/dvdy.20193 | es |
dc.identifier.publicationfirstpage | 191 | es |
dc.identifier.publicationlastpage | 199 | es |
dc.identifier.publicationtitle | Developmental Dynamics | es |
dc.identifier.publicationvolume | 232 | es |
dc.peerreviewed | SI | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |