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dc.contributor.authorBajo Grañeras, Raquel
dc.contributor.authorCrespo Sanjuan, Jesús
dc.contributor.authorGarcía Centeno, Rosa María
dc.contributor.authorGarrote Adrados, José Antonio 
dc.contributor.authorGutiérrez, Gabriel
dc.contributor.authorGarcía Tejeiro, Manuel
dc.contributor.authorAguirre Cervás, Beatriz
dc.contributor.authorCalvo Nieves, María Dolores
dc.contributor.authorBustamante, Rosa
dc.contributor.authorGanfornina Álvarez, María Dolores 
dc.contributor.authorSánchez Romero, Diego 
dc.date.accessioned2014-09-19T16:17:35Z
dc.date.available2014-09-19T16:17:35Z
dc.date.issued2013
dc.identifier.citationInternational Journal of Colorectal Disease, 2013, p. 1-18es
dc.identifier.issn0179-1958es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/6098
dc.descriptionProducción Científicaes
dc.description.abstractPurpose Inverse correlations of apolipoprotein D (ApoD) expression with tumor growth have been shown, therefore proposing ApoD as a good prognostic marker for diverse cancer types, including colorectal cancer (CRC). Besides, ApoD expression is boosted upon oxidative stress (OS) in many pathological situations. This study aims at understanding the role of ApoD in the progression of human CRC. Methods Samples of CRC and distant normal tissue (n051) were assayed for levels of lipid peroxidation, expression profile of OS-dependent genes, and protein expression. Three single-nucleotide polymorphisms in the ApoD gene were analyzed (n0139), with no significant associations found. Finally, we assayed the effect of ApoD in proliferation and apoptosis in the CRC HT-29 cell line.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherSpringer-Verlages
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectColón - Cáncer - Tratamientoes
dc.titleExpression and potential role of apolipoprotein D on the death–survival balance of human colorectal cancer cells under oxidative stress conditionses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1007/s00384-012-1616-2es
dc.identifier.publicationfirstpage1es
dc.identifier.publicationlastpage18es
dc.identifier.publicationtitleInternational Journal of Colorectal Diseasees
dc.peerreviewedSIes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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