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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/61799

    Título
    Impact of oxygen delivery on the development of acute kidney injury in patients undergoing valve heart surgery
    Autor
    Carrasco Serrano, Elena
    Jorge Monjas, PabloAutoridad UVA
    Muñoz Moreno, María FeAutoridad UVA Orcid
    Gómez Sánchez, EstherAutoridad UVA
    Priede Vimbela, Juan Manuel
    Bardají Carrillo, Miguel
    Cubero Gallego, Héctor
    Tamayo Gómez, EduardoAutoridad UVA
    Ortega Loubon, Christian Joseph
    Año del Documento
    2022
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Journal of Clinical Medicine, 2022, Vol. 11, Nº. 11, 3046
    Abstract
    One of the strongest risk factors for death in individuals undergoing cardiac surgery is Cardiac Surgery Associated-Acute Kidney Injury (CSA-AKI). Although the minimum kidney oxygen delivery index (DO2i) during cardiopulmonary bypass (CPB) has been reported, the optimal threshold value has not yet been established. A prospective study was conducted from June 2012 to January 2016 to asses how DO2i influences the pathogenesis of CSA-AKI, as well as its most favorable cut-off value. DO2 levels were recorded at the beginning, middle, and end of the CPB. The association between DO2i and CSA-AKI was investigated using multivariable logistic regression analysis. The optimal cut-off of DO2i as a predictor of CSA-AKI was determined using Classification and Regression Tree (CART) analysis. A total of 782 consecutive patients were enrolled. Of these, 231 (29.5%) patients developed AKI. Optimal DO2i thresholds of 303 mL/min/m2 during the CPB and 295 mL/min/m2 at the end of the intervention were identified, which increased the odds of CSA-AKI almost two-fold (Odds Ratio (OR), 1.90; 95% CI, 1.12–3.24) during the surgery and maintained that risk (OR 1.94; 95% CI, 1.15–3.29) until the end. Low DO2i during cardiopulmonary bypass is a risk factor for CSA-AKI that cannot be ruled out. Continuous renal oxygen supply monitoring for adult patients could be a promising method for predicting AKI during CPB.
    Materias (normalizadas)
    Nephrology
    Kidneys - Diseases
    Riñones - Enfermedades
    Cardiac surgery
    Cardiovascular, aparato - Cirugía
    Heart - Surgery
    Corazón - Cirugía
    Cardiology
    Cardiopulmonary bypass
    Materias Unesco
    3205.06 Nefrología
    3205.01 Cardiología
    ISSN
    2077-0383
    Revisión por pares
    SI
    DOI
    10.3390/jcm11113046
    Version del Editor
    https://www.mdpi.com/2077-0383/11/11/3046
    Propietario de los Derechos
    © 2022 The Authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/61799
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP11 - Artículos de revista [241]
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