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dc.contributor.author | García-Sancho Martín, Francisco Javier | |
dc.contributor.author | Diego, Antonio M. G. de | |
dc.contributor.author | García, Antonio G. | |
dc.date.accessioned | 2014-09-30T16:12:08Z | |
dc.date.available | 2014-09-30T16:12:08Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Pflügers Archiv European Journal of Physiology, 2012, vol. 464, p. 33-41 | es |
dc.identifier.issn | 0031-6768 | es |
dc.identifier.uri | http://uvadoc.uva.es/handle/10324/6341 | |
dc.description | Producción Científica | es |
dc.description.abstract | Chromaffin cells are an excellent model for stimulus– secretion coupling. Ca2+ entry through plasma membrane voltage-operated Ca2+ channels (VOCC) is the trigger for secretion, but the intracellular organelles contribute subtle nuances to the Ca2+ signal. The endoplasmic reticulum amplifies the cytosolic Ca2+ ([Ca2+]C) signal by Ca2+- induced Ca2+ release (CICR) and helps generation of microdomains with high [Ca2+]C (HCMD) at the subplasmalemmal region. These HCMD induce exocytosis of the docked secretory vesicles. Mitochondria close to VOCC take up large amounts of Ca2+ from HCMD and stop progression of the Ca2+ wave towards the cell core. On the other hand, the increase of [Ca2+] at the mitochondrial matrix stimulates respiration and tunes energy production to the increased needs of the exocytic activity. At the end of stimulation, [Ca2+]C decreases rapidly and mitochondria release the Ca2+ accumulated in the matrix through the Na+/Ca2+ exchanger. VOCC, CICR sites and nearby mitochondria form functional triads that co-localize at the subplasmalemmal area, where secretory vesicles wait ready for exocytosis. These triads optimize stimulus–secretion coupling while avoiding propagation of the Ca2+ signal to the cell core. Perturbation of their functioning in neurons may contribute to the genesis of excitotoxicity, ageing mental retardation and/or neurodegenerative disorders. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Springer-Verlag | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Nervioso, Sistema - Enfermedades | es |
dc.subject | Fisiología | |
dc.title | Mitochondria and chromaffin cell function | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1007/s00424-012-1074-2 | es |
dc.identifier.publicationfirstpage | 33 | es |
dc.identifier.publicationlastpage | 41 | es |
dc.identifier.publicationtitle | Pflügers Archiv European Journal of Physiology | es |
dc.identifier.publicationvolume | 464 | es |
dc.peerreviewed | SI | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
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